ArticleFrontiers in cellular neuroscience2013
The possible role of GABAA receptors and gephyrin in epileptogenesis.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- GABASynapse (New York, N.Y.) · 2026Review
- miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.EMBO reports · 2024Article
- miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity.bioRxiv : the preprint server for biology · 2023Article
- GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo.Cellular and molecular life sciences : CMLS · 2023Article
- Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy.Frontiers in synaptic neuroscience · 2022Review
- SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.Cell reports · 2019Article
- Gephyrin: a key regulatory protein of inhibitory synapses and beyond.Histochemistry and cell biology · 2018Review
- Critical roles of αII spectrin in brain development and epileptic encephalopathy.The Journal of clinical investigation · 2018Article
- Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.Neuroscience bulletin · 2017Article
- The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy.Neurobiology of disease · 2015Article
- Human gephyrin is encompassed within giant functional noncoding yin-yang sequences.Nature communications · 2015Article
- Article
- Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.Metabolic brain disease · 2014Article
- Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies.The Lancet. Neurology · 2014Observational
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1 author at 1 institution in 1 country.
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Abstract
The term epileptogenesis refers to a dynamic alteration in neuronal excitability that promotes the appearance of spontaneous seizures. Temporal lobe epilepsy, the most common type of acquired epilepsy, often develops after an insult to the brain such as trauma, febrile seizures, encephalitis, or status epilepticus. During the pre-epileptic state (also referred as latent or silent period) there is a plethora of molecular, biochemical, and structural changes that lead to the generation of recurrent spontaneous seizures (or epilepsy). The specific contribution of these alterations to epilepsy development is unclear, but a loss of inhibition has been associated with the increased excitability detected in the latent period. A rapid increase in neuronal hyperexcitability could be due, at least in part, to a decline in the number of physiologically active GABAA receptors (GABAAR). Altered expression of scaffolding proteins involved in the trafficking and anchoring of GABAAR could directly impact the stability of GABAergic synapses and promote a deficiency in inhibitory neurotransmission. Uncovering the molecular mechanisms operating during epileptogenesis and its possible impact on the regulation of GABAAR and scaffolding proteins may offer new targets to prevent the development of epilepsy.
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