ArticleClinical and vaccine immunology : CVI2013
Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis.
Article in Clinical and vaccine immunology : CVI, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Analysis of efficacy obtained with a trivalent inactivatedCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017Trial
- Minimum dose, antigen content, and immunization duration of a trivalent vaccine of inactivatedCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2016Trial
- Integration of bulk RNA-seq and scRNA-seq reveals cell subsets and gene signatures associated with Glaesserella parasuis infection.BMC genomics · 2026Article
- Proteomics- and immunoinformatics-based design of a multi-epitope vaccine ZZ1 against Glaesserella parasuis.BMC veterinary research · 2026Article
- Capsular immunity is necessary for protection against some but not all strains of Glaesserella parasuis.Veterinary microbiology · 2025Article
- Host factor Rab4b mediates internalization and intoxication of 3D4/21 cells by the active subunit of theFrontiers in microbiology · 2025Article
- TbpB-based oral mucosal vaccine provides heterologous protection against Glässer's disease caused by different serovars of Spanish field isolates of Glaesserella parasuis.Porcine health management · 2024Article
- Rab4b Promotes Cytolethal Distending Toxin fromToxins · 2024Article
- Pili Subunit PilA Contributes to the Cytoadhesion ofApplied and environmental microbiology · 2023Article
- Molecular Characterization and Phylogenetic Analysis ofPathogens (Basel, Switzerland) · 2023Article
- Screening of linear B-cell epitopes and its proinflammatory activities ofFrontiers in cellular and infection microbiology · 2023Article
- Pleural thickening induced byFrontiers in cellular and infection microbiology · 2022Article
- Characterization and protective activity of monoclonal antibodies directed against Fe (3+) ABC transporter substrate-binding protein of Glaesserella parasuis.Veterinary research · 2021Article
- Altered Nasal Microbiota Composition Associated with Development of Polyserositis byPathogens (Basel, Switzerland) · 2021Article
- Serotyping and pathotyping of Glaesserella parasuis isolated 2012-2019 in Germany comparing different PCR-based methods.Veterinary research · 2020Article
- Evaluation of the recombinant proteins RlpB and VacJ as a vaccine for protection against Glaesserella parasuis in pigs.BMC veterinary research · 2020Article
- Whole-genome sequence analyses ofPeerJ · 2020Article
- Antimicrobial removal on piglets promotes health and higher bacterial diversity in the nasal microbiota.Scientific reports · 2019Article
- Characterization ofOpen life sciences · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haemophilus parasuis causes Glässer's disease, a syndrome of polyserositis, meningitis, and arthritis in swine. Previous studies with H. parasuis have revealed virulence disparity among isolates and inconsistent heterologous protection. In this study, virulence, direct transmission, and heterologous protection of 4 isolates of H. parasuis (SW114, 12939, MN-H, and 29755) were evaluated using a highly susceptible pig model. In an initial experiment, isolates 12939, MN-H, and 29755 caused Glässer's disease, while strain SW114 failed to cause any clinical signs of disease. One pig from each group challenged with MN-H or 29755 failed to develop clinical disease but was able to transmit H. parasuis to noninfected pigs, which subsequently developed Glässer's disease. Pigs colonized with SW114, 29755, or MN-H that were free of clinical disease were protected from a subsequent challenge with isolate 12939. In a following experiment, pigs vaccinated with strain SW114 given as either a bacterin intramuscularly or a live intranasal vaccine were protected from subsequent challenge with isolate 12939; however, some pigs given live SW114 developed arthritis. Overall these studies demonstrated that pigs infected with virulent isolates of H. parasuis can remain healthy and serve as reservoirs for transmission to naive pigs and that heterologous protection among H. parasuis isolates is possible. In addition, further attenuation of strain SW114 is necessary if it is to be used as a live vaccine.
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