ArticleJournal of clinical microbiology2013
Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Reporting practices for genomic epidemiology of tuberculosis: a systematic review of the literature using STROME-ID guidelines as a benchmark.The Lancet. Microbe · 2021Pooled it
- Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review.BMC medicine · 2016Pooled it
- Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region.The American journal of tropical medicine and hygiene · 2023Article
- Investigating the intensity of social contacts associated with tuberculosis: a weighted networks model.BMC pulmonary medicine · 2023Article
- Characterization of Mutations Associated with Streptomycin Resistance in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Low-Level Rifampin Resistance andJournal of clinical microbiology · 2021Article
- Genomic Analysis of Multidrug-ResistantFrontiers in genetics · 2021Article
- Genetic Diversity inAnnual review of genetics · 2020Review
- Circulation ofPathogens and global health · 2019Review
- Global expansion ofScience advances · 2018Article
- Importance of differential identification of Mycobacterium tuberculosis strains for understanding differences in their prevalence, treatment efficacy, and vaccine development.Journal of microbiology (Seoul, Korea) · 2018Review
- A Nonsynonymous SNP Catalog of Mycobacterium tuberculosis Virulence Genes and Its Use for Detecting New Potentially Virulent Sublineages.Genome biology and evolution · 2017Article
- Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.Nature genetics · 2016Article
- First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.Journal of clinical microbiology · 2016Article
- Whole genome sequencing to complement tuberculosis drug resistance surveys in Uganda.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis.The Lancet. Respiratory medicine · 2015Article
- The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Map the gap: missing children with drug-resistant tuberculosis.Public health action · 2015Article
- Article
- Mycobacterium tuberculosis isolates from single outpatient clinic in Panama City exhibit wide genetic diversity.The American journal of tropical medicine and hygiene · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidrug-resistant tuberculosis (MDR-TB) is a significant health problem in Panama. The extent to which such cases are the result of primary or acquired resistance and the strain families involved are unknown. We performed whole-genome sequencing of a collection of 66 clinical MDR isolates, along with 31 drug-susceptible isolates, that were isolated in Panama between 2001 and 2010; 78% of the MDR isolates belong to the Latin American-Mediterranean (LAM) family. Drug resistance mutations correlated well with drug susceptibility profiles. To determine the relationships among these strains and to better understand the acquisition of resistance mutations, a phylogenetic tree was constructed based on a genome-wide single-nucleotide polymorphism analysis. The phylogenetic tree shows that the isolates are highly clustered, with a single strain (LAM9-c1) accounting for nearly one-half of the MDR isolates (29/66 isolates). The LAM9-c1 strain was most prevalent among male patients of working age and was associated with high mortality rates. Members of this cluster all share identical mutations conferring resistance to isoniazid (KatG S315T mutation), rifampin (RpoB S531L mutation), and streptomycin (rrs C517T mutation). This evidence of primary resistance supports a model in which MDR-TB in Panama is driven by clonal expansion and ongoing transmission of several strains in the LAM family, including the highly successful MDR strain LAM9-c1. The phylogenetic analysis also shows that the LAM9-c1 strain is closely related to the KwaZulu-Natal (KZN) extensively drug-resistant TB strain identified in KwaZulu-Natal, South Africa. The LAM9-c1 and KZN strains likely arose from a recent common ancestor that was transmitted between Panama and South Africa and had the capacity to tolerate an accumulation of multiple resistance mutations.
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