ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Granule cell ascending axon excitatory synapses onto Golgi cells implement a potent feedback circuit in the cerebellar granular layer.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 77 citations in OpenAlex.
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Temporal dynamics between the whisker sensorimotor cortex and the olivocerebellar module in awake mice.Frontiers in cellular neuroscience · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- A computational model of the cerebellar granular layer calibrated to experimental data for studying inhibition and sensory encoding.Scientific reports · 2025Article
- Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells.Communications biology · 2025Article
- The cerebellum converts input data into a hyper low-resolution granule cell code with spatial dimensions: a hypothesis.Royal Society open science · 2025Article
- Computational anatomy: the cerebellar microzone computation.Oxford open neuroscience · 2025Article
- Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis.Cerebellum (London, England) · 2024Article
- Increased understanding of complex neuronal circuits in the cerebellar cortex.Frontiers in cellular neuroscience · 2024Review
- Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer.Biomedicines · 2022Article
- Model simulations unveil the structure-function-dynamics relationship of the cerebellar cortical microcircuit.Communications biology · 2022Article
- How and Why the Cerebellum Recodes Input Signals: An Alternative to Machine Learning.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- The Cerebellar Involvement in Autism Spectrum Disorders: From the Social Brain to Mouse Models.International journal of molecular sciences · 2022Review
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Article
- Multidimensional population activity in an electrically coupled inhibitory circuit in the cerebellar cortex.Neuron · 2021Article
- Calcium Channel-Dependent Induction of Long-Term Synaptic Plasticity at Excitatory Golgi Cell Synapses of Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Accounting for uncertainty: inhibition for neural inference in the cerebellum.Proceedings. Biological sciences · 2021Review
- Projection-dependent heterogeneity of cerebellar granule cell calcium responses.Molecular brain · 2021Article
- Chronic Ethanol Exposure Enhances Facial Stimulation-Evoked Mossy Fiber-Granule Cell Synaptic TransmissionFrontiers in systems neuroscience · 2021Article
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Authors and funding
7 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of inhibitory interneurons within brain microcircuits depends critically on the nature and properties of their excitatory synaptic drive. Golgi cells (GoCs) of the cerebellum inhibit cerebellar granule cells (GrCs) and are driven both by feedforward mossy fiber (mf) and feedback GrC excitation. Here, we have characterized GrC inputs to GoCs in rats and mice. We show that, during sustained mf discharge, synapses from local GrCs contribute equivalent charge to GoCs as mf synapses, arguing for the importance of the feedback inhibition. Previous studies predicted that GrC-GoC synapses occur predominantly between parallel fibers (pfs) and apical GoC dendrites in the molecular layer (ML). By combining EM and Ca(2+) imaging, we now demonstrate the presence of functional synaptic contacts between ascending axons (aa) of GrCs and basolateral dendrites of GoCs in the granular layer (GL). Immunohistochemical quantification estimates these contacts to be ∼400 per GoC. Using Ca(2+) imaging to identify synaptic inputs, we show that EPSCs from aa and mf contacts in basolateral dendrites display similarly fast kinetics, whereas pf inputs in the ML exhibit markedly slower kinetics as they undergo strong filtering by apical dendrites. We estimate that approximately half of the local GrC contacts generate fast EPSCs, indicating their basolateral location in the GL. We conclude that GrCs, through their aa contacts onto proximal GoC dendrites, define a powerful feedback inhibitory circuit in the GL.
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