ArticleEuropean journal of epidemiology2013
Triptan safety during pregnancy: a Norwegian population registry study.
Article in European journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Sex-specific management of migraine a systematic review and consensus statement from the European Headache Federation (EHF).The journal of headache and pain · 2026Pooled it
- A systematic review and meta-analyses on the prevalence of pregnancy outcomes in migraine treated patients: a contribution from the IMI2 ConcePTION project.Journal of neurology · 2022Pooled it
- Headache and pregnancy: a systematic review.The journal of headache and pain · 2017Pooled it
- Review
- Review
- Triptan overuse during pregnancy: a possible cause of placental hypoperfusion.European journal of clinical pharmacology · 2021Article
- Perinatal use of triptans and other drugs for migraine-A nationwide drug utilization study.PloS one · 2021Article
- Sex and Gender Differences in Migraine-Evaluating Knowledge Gaps.Journal of women's health (2002) · 2018Article
- EUROmediCAT signal detection: an evaluation of selected congenital anomaly-medication associations.British journal of clinical pharmacology · 2016Article
- Review
- Managing Migraine During Pregnancy and Lactation.Current neurology and neuroscience reports · 2016Review
- Prenatal Triptan Exposure and Internalising and Externalising Behaviour Problems in 3-Year-Old Children: Results from the Norwegian Mother and Child Cohort Study.Paediatric and perinatal epidemiology · 2016Article
- Cluster Headache: Special Considerations for Treatment of Female Patients of Reproductive Age and Pediatric Patients.Current neurology and neuroscience reports · 2016Review
- The Rotterdam Study: 2016 objectives and design update.European journal of epidemiology · 2015Article
- Drug therapy in headache.Clinical medicine (London, England) · 2015Review
- Pharmacological treatment of migraine during pregnancy and breastfeeding.Nature reviews. Neurology · 2015Review
- Cost-effectiveness of stimulation of the sphenopalatine ganglion (SPG) for the treatment of chronic cluster headache: a model-based analysis based on the Pathway CH-1 study.The journal of headache and pain · 2015Article
- The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge on triptan safety during pregnancy remains limited to their class effect or studies on sumatriptan. Our aim was to evaluate the individual effect of four most frequently used triptans on several pregnancy outcomes. We used the Norwegian prescription database to access information on triptans redeemed by pregnant women living in Norway between 2004 and 2007. This database was linked to the Medical Birth Registry of Norway covering every institutional delivery in Norway and providing information on pregnancy, delivery, maternal and neonatal health. Estimates of associations with pregnancy outcomes were obtained by Generalised Estimation Equations analysis. Of the 181,125 women in our study, 1,465 (0.8%) redeemed triptans during pregnancy, and 1,095 (0.6%) redeemed triptans before pregnancy only (disease comparison group). The population comparison group comprised the remaining 178,565 women. Using this group as reference, we found no associations between triptan redemption during pregnancy and congenital malformations. Second trimester redemption was associated with postpartum haemorrhage (adjusted OR 1.57; 95% CI 1.19-2.07). The disease comparison group had an increased risk of major congenital malformations (adjusted OR 1.48; 95% CI 1.11-1.97), low birth weight (adjusted OR 1.39; 95% CI 1.08-1.81), and preterm birth (adjusted OR 1.30; 95% CI 1.06-1.60). The association of triptans with postpartum hemorrhage could be attributable to decreased platelet agreeability occurring in severe migraine. Likewise, the increased risk of major congenital malformations and other adverse pregnancy outcomes in the disease comparison group might be attributable to migraine severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.