Evidence map›Paper›PMID 23884722›Full record

ReviewCurrent neurology and neuroscience reports2013

The variegate neurological manifestations of varicella zoster virus infection.

Don Gilden, Maria A Nagel, Randall J Cohrs, Ravi Mahalingam

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  11. Review
  12. Zoster Polyneuritis Cranialis and Intracranial Vasculopathy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Neurology of Acute Viral Infections.The Neurohospitalist · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Don GildenDepartment of Neurology and Microbiology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Box B182, Aurora, CO 80045, USA. don.gilden@ucdenver.edu
Maria A Nagel
Randall J Cohrs
Ravi Mahalingam
University of Colorado Denver · US

Funding

VARICELLA ZOSTER VIRUS VASCULOPATHY: CHANGING CLINICAL PRACTICEP01AG032958 · NIA · UNIVERSITY OF COLORADO DENVER · PI MAHALINGAM, RAVI · 2009 to 2023
$30.3M
NEUROBIOLOGY OF VARICELLA-ZOSTER VIRUSR01AG006127 · NIA · UNIVERSITY OF COLORADO DENVER · PI GILDEN, DONALD · 1987 to 2014
$4.2M
NEUROBIOLOGY OF VARICELLA ZOSTER VIRUSR37AG006127 · NIA · UNIVERSITY OF COLORADO DENVER · PI GILDEN, DONALD H · 1995 to 2004
$2.3M
Prevention of VZV ReactivationR01NS082228 · NINDS · UNIVERSITY OF COLORADO DENVER · PI COHRS, RANDALL J. · 2013 to 2017
$1.7M
Purinergic Signaling in Varicella Zoster Virus VasculopathyR01NS094758 · NINDS · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2015 to 2018
$1.4M
Mechanisms by which VZV IE proteins interact with cell antiviral proteins to prevK08NS067070 · NINDS · UNIVERSITY OF COLORADO DENVER · PI NAGEL, MARIA ACENA · 2009 to 2013
$895k
NIA NIH HHS AG006127NIA NIH HHS AG032958NIA NIH HHS P01 AG032958NIA NIH HHS R01 AG006127NIA NIH HHS R37 AG006127NINDS NIH HHS K08 NS067070NINDS NIH HHS NS067070NINDS NIH HHS NS082228NINDS NIH HHS R01 NS082228NINDS NIH HHS R01 NS094758
6 · The paper itself

Abstract

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which the virus becomes latent in ganglionic neurons along the entire neuraxis. With advancing age or immunosuppression, cell-mediated immunity to VZV declines, and the virus reactivates to cause zoster (shingles), dermatomal distribution, pain, and rash. Zoster is often followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, vasculopathy, meningoencephalitis, and multiple ocular disorders. This review covers clinical, laboratory, and pathological features of neurological complications of VZV reactivation, including diagnostic testing to verify active VZV infection in the nervous system. Additional perspectives are provided by discussions of VZV latency, animal models to study varicella pathogenesis and immunity, and of the value of vaccination of elderly individuals to boost cell-mediated immunity to VZV and prevent VZV reactivation.

Indexed as

AnimalsDisease Models, AnimalHerpesvirus 3, HumanHerpes ZosterHumansNervous System DiseasesNeuralgia, PostherpeticVirus Latency

Identifiers

PMID23884722
PMCPMC4051361
OpenAlexW2016913660

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.