ArticleCurrent microbiology2013
Molecular detection of HpmA and HlyA hemolysin of uropathogenic Proteus mirabilis.
Article in Current microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- The agroenvironmental-clinical link of Proteus mirabilis: Genomic epidemiology, clonal relationships, and shared resistance and virulence profiles.Folia microbiologica · 2026Article
- Biofilm Formation, Virulence-Associated Genes, and Antimicrobial Resistance inMicroorganisms · 2026Article
- Isolation, Identification and Pathogenicity Analysis of Proteus mirabilis in Cynomolgus Monkey From Yunnan, China.Veterinary medicine and science · 2026Article
- A One Health Perspective onMicroorganisms · 2026Review
- Review
- Virulence and Antibiotic Resistance Profiles of Proteus mirabilis Strains Isolated From Broiler Chickens: Implications for Poultry and Public Health.Veterinary medicine and science · 2025Article
- Biofilm formation ability and swarming motility are associated with some virulence genes in Proteus mirabilis.BMC microbiology · 2025Article
- Multidrug resistance and virulence profile of the commensal Proteus mirabilis isolated from a native Iraqi frozen chicken carcass.Journal, genetic engineering & biotechnology · 2025Article
- Clonal Dissemination of NDM-ProducingPathogens (Basel, Switzerland) · 2025Article
- Impact of COVID-19 pandemic on antimicrobial resistance of Proteus mirabilis in a Brazilian hospital.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Distribution of multidrug-resistantVeterinary world · 2025Article
- Assessment of typing methods, virulence genes profile and antimicrobial susceptibility for clinical isolates of Proteus mirabilis.Annals of clinical microbiology and antimicrobials · 2025Article
- Microbial flora of the respiratory tract and skin of artisanal municipal solid waste handlers in Aba, Abia State, Nigeria.Access microbiology · 2025Article
- Potential antivirulence activity of sub-inhibitory concentrations of ciprofloxacin against Proteus mirabilis isolates: an in-vitro and in-vivo study.Annals of clinical microbiology and antimicrobials · 2024Article
- Emergence and genomic chion of Proteus mirabilis harboring blaVeterinary research · 2024Article
- Antibiotic resistance and virulence profiles of Proteus mirabilis isolated from broiler chickens at abattoir in South Africa.Veterinary medicine and science · 2024Article
- Overview ofFrontiers in microbiology · 2024Review
- A correlation study between virulence factors and multidrug resistance among clinical isolates of Proteus mirabilis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- In Vivo Role of Two-Component Regulatory Systems in Models of Urinary Tract Infections.Pathogens (Basel, Switzerland) · 2023Review
- Genetic analysis of resistance and virulence characteristics of clinical multidrug-resistantFrontiers in cellular and infection microbiology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infection (UTI) is one of the bacterial infections frequently documented in humans. Proteus mirabilis is associated with UTI mainly in individuals with urinary tract abnormality or related with vesicular catheterism and it can be difficult to treat because of the formation of stones in the bladder and kidneys. These stones are formed due to the presence of urease synthesized by the bacteria. Another important factor is that P. mirabilis produces hemolysin HpmA, used by the bacteria to damage the kidney tissues. Proteus spp. samples can also express HlyA hemolysin, similar to that found in Escherichia coli. A total of 211 uropathogenic P. mirabilis isolates were analyzed to detect the presence of the hpmA and hpmB genes by the techniques of polymerase chain reaction (PCR) and dot blot and hlyA by PCR. The hpmA and hpmB genes were expressed by the RT-PCR technique and two P. mirabilis isolates were sequenced for the hpmA and hpmB genes. The presence of the hpmA and hpmB genes was confirmed by PCR in 205 (97.15 %) of the 211 isolates. The dot blot confirmed the presence of the hpmA and hpmB genes in the isolates that did not amplify in the PCR. None of the isolates studied presented the hlyA gene. The hpmA and hpmB genes that were sequenced presented 98 % identity with the same genes of the HI4320 P. mirabilis sample. This study showed that the PCR technique has good sensitivity for detecting the hpmA and hpmB genes of P. mirabilis.
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