ReviewExperimental physiology2013
Pacemaking kisspeptin neurons.
Review in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Neuronal plasticity at puberty in mouse hypothalamicProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of menopause on temperature regulation.Temperature (Austin, Tex.) · 2025Review
- New methods to investigate the GnRH pulse generator.Journal of molecular endocrinology · 2024Review
- Article
- Adaptive Resetting of Tuberoinfundibular Dopamine (TIDA) Network Activity during Lactation in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling.The Journal of clinical endocrinology and metabolism · 2019Article
- Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.Hormones and behavior · 2018Review
- Kv4.2 channel activity controls intrinsic firing dynamics of arcuate kisspeptin neurons.The Journal of physiology · 2018Article
- Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates.Frontiers in endocrinology · 2018Review
- Long-Term Recordings of Arcuate Nucleus Kisspeptin Neurons Reveal Patterned Activity That Is Modulated by Gonadal Steroids in Male Mice.Endocrinology · 2017Article
- Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction.Journal of neuroendocrinology · 2016Review
- Relative Importance of the Arcuate and Anteroventral Periventricular Kisspeptin Neurons in Control of Puberty and Reproductive Function in Female Rats.Endocrinology · 2015Article
- Estradiol Membrane-Initiated Signaling and Female Reproduction.Comprehensive Physiology · 2015Review
- Sex differences in the neurobiology of epilepsy: a preclinical perspective.Neurobiology of disease · 2014Review
- Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Electrophysiology of arcuate neurokinin B neurons in female Tac2-EGFP transgenic mice.Endocrinology · 2014Article
- Loss of the Habenula Intrinsic Neuromodulator Kisspeptin1 Affects Learning in Larval Zebrafish.eNeuroArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Kisspeptin (Kiss1) neurons are vital for reproduction. Gonatotrophin-releasing hormone (GnRH) neurons express the kisspeptin receptor (GPR54), and kisspeptins potently stimulate the release of GnRH by depolarizing and inducing sustained action potential firing in GnRH neurons. As such, Kiss1 neurons may be the presynaptic pacemaker neurons in the hypothalamic circuitry that controls reproduction. There are at least two different populations of Kiss1 neurons; one in the rostral periventricular area (RP3V) that is stimulated by oestrogens and the other in the arcuate nucleus that is inhibited by oestrogens. How each of these Kiss1 neuronal populations participates in the regulation of the reproductive cycle is currently under intense investigation. Based on electrophysiological studies in the guinea-pig and mouse, Kiss1 neurons in general are capable of generating burst-firing behaviour. Essentially, all Kiss1 neurons, which have been studied thus far in the arcuate nucleus, express the ion channels necessary for burst firing, which include hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels and the T-type calcium (Cav3.1) channels. In voltage-clamp conditions, these channels produce distinct currents that can generate burst-firing behaviour in current-clamp conditions. The future challenge is to identify other key channels and synaptic inputs involved in the regulation of the firing properties of Kiss1 neurons and the physiological regulation of the expression of these channels and receptors by oestrogens and other hormones. The ultimate goal is to understand how Kiss1 neurons control the different phases of GnRH neurosecretion, hence reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.