Trial reportEuropean radiology2013
Whole-body diffusion-weighted imaging: is it all we need for detecting metastases in melanoma patients?
Trial report in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06071195 (All-in-One Prostate Cancer Staging with MRI), which is not on this map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
All-in-One Prostate Cancer Staging with MRI
Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: the Streamline diagnostic accuracy studies.Health technology assessment (Winchester, England) · 2019Trial
- Whole-body magnetic resonance imaging for cutaneous melanoma staging: A scientific review.World journal of clinical oncology · 2025Article
- Total Body PET/MRI as a Gold Standard for Staging Breast Cancer During Pregnancy in a Case Report.Breast cancer : basic and clinical research · 2025Article
- Present and future of whole-body MRI in metastatic disease and myeloma: how and why you will do it.Skeletal radiology · 2024Review
- Whole-body MRI in oncology: acquisition protocols, current guidelines, and beyond.La Radiologia medica · 2024Review
- Evaluating the diagnostic efficacy of whole-body MRI versusScientific reports · 2024Article
- Article
- Patient centered radiology: investigating 3 Tesla whole body MRI acceptance in cancer patients.La Radiologia medica · 2023Article
- Whole-Body Magnetic Resonance Imaging (MRI) for Staging Melanoma Patients in Direct Comparison to Computed Tomography (CT): Results from a Prospective Positron Emission Tomography (PET)/CT and PET/MRI Study.Diagnostics (Basel, Switzerland) · 2023Article
- Melanoma Brain Metastases: A Systematic Review of Opportunities for Earlier Detection, Diagnosis, and Treatment.Life (Basel, Switzerland) · 2023Review
- Is whole-body magnetic resonance imaging a source of anxiety in oncological patients?Cancer reports (Hoboken, N.J.) · 2023Article
- Clinical Evaluation of an Abbreviated Contrast-Enhanced Whole-Body MRI for Oncologic Follow-Up Imaging.Diagnostics (Basel, Switzerland) · 2021Article
- Preliminary observations regarding the expectations, acceptability and satisfaction of whole-body MRI in self-referring asymptomatic subjects.The British journal of radiology · 2021Article
- Whole-Body MRI for the Detection of Recurrence in Melanoma Patients at High Risk of Relapse.Cancers · 2021Article
- Whole-body magnetic resonance imaging: technique, guidelines and key applications.Ecancermedicalscience · 2021Review
- What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century.The British journal of radiology · 2020Review
- The role of diffusion-weighted and dynamic contrast enhancement perfusion-weighted imaging in the evaluation of salivary glands neoplasms.La Radiologia medica · 2020Article
- Whole-body magnetic resonance imaging (WB-MRI) for cancer screening in asymptomatic subjects of the general population: review and recommendations.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Review
- Imaging of pediatric cutaneous melanoma.Pediatric radiology · 2019Review
- Primary hepatic melanoma: A case report of computed tomography and magnetic resonance imaging findings.Medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether whole-body diffusion-weighted imaging (WB-DWI) alone is adequate for detecting metastases in melanoma patients, or if standard WB contrast-enhanced magnetic resonance imaging (WB-ceMRI) is required.
methodsSeventy-one WB-DWI studies were performed quarterly along with whole-body MRI including contrast-enhanced sequences (WB-ceMRI) in 19 patients with advanced melanoma. The reference standard was biopsy, other imaging investigations, or changes observed on follow-up. Findings of metastasis in separate WB-DWI and WB-DWI + WB-ceMRI readings were compared using κ statistics. Additionally, the distribution of findings was examined and calculated per body region (brain, neck, chest, abdomen, liver, pelvis, subcutaneous tissues, bones) and diagnostic accuracy (DA), sensitivity, specificity, negative predictive value, and positive predictive value were calculated per patient.
resultsThe eight examinations that were positive by the reference standard contained a total of 14 metastatic findings. With almost perfect agreement between techniques (κ = 85 %, 95 % CI 70-100 %) for detection of examinations with metastatic findings, and complete agreement in extracranial metastasis detection, 10 metastases were detected using WB-DWI and 13 using WB-DWI + WB-ceMRI. WB-DWI and WB-DWI + WB-MRI had equivalent per patient DA (79 %).
conclusionsWB-DWI without additional WB-ceMRI sequences is promising for the detection of extracranial metastases in melanoma patients, but contrast-enhanced MRI is required for evaluating the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.