Evidence map›Paper›PMID 23884276›Full record

ArticleObstetrics and gynecology2013

Vitamin K deficiency bleeding and early infant male circumcision in Africa.

Rebeca M Plank, Tara Steinmetz, David C Sokal, Martin J Shearer, Santorino Data

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Single-arm evaluation of the AccuCirc device for early infant male circumcision in Botswana.Journal of acquired immune deficiency syndromes (1999) · 2014
    Trial
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebeca M PlankDivision of Infectious Disease, Brigham and Women's Hospital, Boston, Massachusetts; Botswana-Harvard Partnership for HIV Research and Education, Gaborone, Botswana; the Department of Public Policy, Duke University, Durham, North Carolina; the Clinical Sciences Department, FHI 360, Durham, North Carolina; the Haemostasis Research Unit, Centre for Haemostasis & Thrombosis, St. Thomas' Hospital, London, United Kingdom; and the Department of Pediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda.
Tara Steinmetz
David C Sokal
Martin J Shearer
Santorino Data
University of Botswana · BW

Funding

BUILDING HUMAN RESOURCE CAPACITY TO SUPPORT PREVENTION, CARE & TREATMENT, STRATEGU2GPS000941 · PS · PREMIERE · PI WILSON, CAROLYN JUNE · 2008 to 2012
$8.8M
Infant Male Circumcision in Botswana: Feasibility, Safety and AcceptabilityK23AI084579 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PLANK, REBECA MILANESI · 2009 to 2012
$548k
NCHHSTP CDC HHS U2G PS000941NIAID NIH HHS 5K23AI084579NIAID NIH HHS K23 AI084579PEPFARPHS HHS U2GPS000941-01
6 · The paper itself

Abstract

backgroundEarly infant (1-60 days of life) male circumcision is being trialed in Africa as a human immunodeficiency virus prevention strategy. Postcircumcision bleeding is particularly concerning where most infants are breastfed, and thus these infants are at increased risk of vitamin K deficiency bleeding. CASE: During a circumcision trial, one infant bled for 90 minutes postprocedure. After discovering he had not received standard prophylactic vitamin K, we gave 2 mg phytomenadione (vitamin K1) intramuscularly; bleeding stopped within 30 minutes.

conclusionVitamin K's extremely rapid action is not commonly appreciated. Neonatal vitamin K has been shown to be cost-effective. To increase availability and promote awareness of its importance, especially in low-resource settings where blood products and transfusions are limited, vitamin K should be included in the World Health Organization's Model List of Essential Medicines for Children.

Indexed as

AfricaCircumcision, MaleHemorrhageHumansInfant, NewbornMaleVitamin K 1Vitamin K DeficiencyVitaminsVitamin K 1Vitamins

Identifiers

PMID23884276
PMCPMC3773869
OpenAlexW2315756582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.