ArticleNanoscale2013
Gadolinium embedded iron oxide nanoclusters as T1-T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery.
Article in Nanoscale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 49 citations in OpenAlex.
- Rational Design of Magnetic Nanoparticles as TMolecules (Basel, Switzerland) · 2024Review
- Construction of nanomaterials as contrast agents or probes for glioma imaging.Journal of nanobiotechnology · 2021Review
- Mn(ii) chelate-coated superparamagnetic iron oxide nanocrystals as high-efficiency magnetic resonance imaging contrast agents.Nanoscale advances · 2020Article
- Investigating the Size and Microstrain Influence in the Magnetic Order/Disorder State of GdCuNanomaterials (Basel, Switzerland) · 2020Article
- Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics.Theranostics · 2020Review
- Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging.Advanced materials (Deerfield Beach, Fla.) · 2019Review
- Gadolinium-labelled iron/iron oxide core/shell nanoparticles asRSC advances · 2018Article
- Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics.Chemical Society reviews · 2018Review
- Inorganic Nanocarriers Overcoming Multidrug Resistance for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2016Article
- Imaging-guided delivery of RNAi for anticancer treatment.Advanced drug delivery reviews · 2016Review
Corrections and comments
- Expression of concern
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
This report illustrates a new strategy of designing a T1-T2 dual-modal magnetic resonance imaging (MRI)-visible vector for siRNA delivery and MRI. Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). The resulting water-dispersible GdIO-stPEI nanoclusters possess good stability, monodispersity with narrow size distribution and competitive T1-T2 dual-modal MR imaging properties. The nanocomposite system is capable of binding and delivering siRNA for knockdown of a gene of interest while maintaining its magnetic properties and biocompatibility. This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T1-T2 dual-modal MRI monitoring capability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.