ArticleMolecules (Basel, Switzerland)2013
Preventive effects of Eleutherococcus senticosus bark extract in OVX-induced osteoporosis in rats.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- UHPLC-DAD/ESI-TOF-MS Phytochemical Characterization and Evaluation of the Impact ofInternational journal of molecular sciences · 2024Article
- Vigeo attenuates cartilage and bone destruction in a collagen‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines.Experimental and therapeutic medicine · 2024Article
- Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials.Journal of traditional and complementary medicine · 2024Review
- Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.Experimental animals · 2023Article
- Tea saponin additive to extract eleutheroside B and E from Eleutherococcus senticosus by ultrasonic mediation and its application in a semi-pilot scale.Ultrasonics sonochemistry · 2022Article
- Anti-Osteoporosis Effects of theNutrients · 2021Article
- Spontaneous activities in baroreflex afferent pathway contribute dominant role in parasympathetic neurocontrol of blood pressure regulation.CNS neuroscience & therapeutics · 2018Article
- Therapeutic Effect of Cistanoside A on Bone Metabolism of Ovariectomized Mice.Molecules (Basel, Switzerland) · 2017Article
- The effects of Lycii Radicis Cortex on RANKL-induced osteoclast differentiation and activation in RAW 264.7 cells.International journal of molecular medicine · 2016Article
- Preventive effects of Citrus unshiu peel extracts on bone and lipid metabolism in OVX rats.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eleutherococcus senticosus (Siberian ginseng), has been used as a powerful tonic herb with an impressive range of health benefits. This medicinal herb has been commonly used to treat bone metabolism diseases due to its traditional Korean medicine use to strengthen muscle and bone. This study was conducted to investigate prevention of bone loss by a standardized extract of dried E. senticosus stem bark in an ovariectomized (OVX) rat model of osteoporosis. The OVX groups were divided into five groups treated with distilled water, 17β-estradiol (E2 10 μg/kg, once daily, i.p) and dried stem bark of E. senticosus extracts (DES 10, 30, and 100 mg/kg, once daily, p.o) for eight weeks, respectively. After eight weeks of treatments, the femur bone mineral density of the 100 mg/kg DES-treated group was significantly higher than that of the OVX-control group (16.7%, p < 0.01) without affecting the body, organs, and uterus weights, and serum estradiol levels. Additionally, bone markers such as serum ALP, CTx, and OC levels were significantly decreased in the DES 100 mg/kg treated group. These results show that DES is able to prevent OVX-induced in bone loss without the influence of hormones such as estrogen.
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