ArticleMolecules (Basel, Switzerland)2013
In vitro antimicrobial activity of plant-derived diterpenes against bovine mastitis bacteria.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Protective effect of snail secretion filtrate in an in vitro model of mastitis.Veterinary record open · 2026Article
- Nanoencapsulation and antimicrobial activities of Commiphora swynnertonii resin against multidrug-resistant Staphylococcus aureus strains from mastitis cow patients.Discover nano · 2026Article
- Major Low-Molecular-Weight Metabolites from Freshwater Aquatic Macrophytes: Ecological Aspects.Molecules (Basel, Switzerland) · 2026Article
- Zataria multiflora essential oil: a potent agent with antibacterial, anti-NorA efflux pump and anti-biofilm activity against ciprofloxacin-resistant Staphylococcus aureus isolates from bovine mastitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Bovine mastitis, a worldwide impact disease: Prevalence, antimicrobial resistance, and viable alternative approaches.Veterinary and animal science · 2023Review
- Deciphering the antimicrobial, antibiofilm and membrane stabilizing synergism ofBiotechnology reports (Amsterdam, Netherlands) · 2023Article
- Article
- The Role ofMicroorganisms · 2021Review
- Verification of Chromatographic Profile of Primary Essential Oil ofMolecules (Basel, Switzerland) · 2020Article
- Control of Bovine Mastitis: Old and Recent Therapeutic Approaches.Current microbiology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the antibacterial activity of three diterpenes isolated from natural sources against a panel of microorganisms responsible for bovine mastitis. ent-Copalic acid (CA) was the most active metabolite, with promising MIC values (from 1.56 to 6.25 µg mL-1) against Staphylococcus aureus (ATCC and clinical isolate), Staphylococcus epidermidis, Streptococcus agalactiae, and Streptococcus dysgalactiae. We conducted time-kill assays of CA against S. aureus, a commensal organism considered to be a ubiquitous etiological agent of bovine mastitis in dairy farms worldwide. In the first 12 h, CA only inhibited the growth of the inoculums (bacteriostatic effect), but its bactericidal effect was clearly noted thereafter (between 12 and 24 h). In conclusion, CA should be considered for the control of several Gram-positive bacteria related to bovine mastitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.