ArticleParasites & vectors2013
Identification and characterization of microRNAs in Baylisascaris schroederi of the giant panda.
Article in Parasites & vectors, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 16 citations in OpenAlex.
- A rare case of giant panda cancer: Pancreatic ductal adenocarcinoma.Animal models and experimental medicine · 2022Article
- A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway.Parasites & vectors · 2022Article
- Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells.Parasites & vectors · 2022Article
- Review on parasites of wild and captive giant pandas (International journal for parasitology. Parasites and wildlife · 2020Review
- Comparative analysis of microRNA profiles between wild and cultured Haemaphysalis longicornis (Acari, Ixodidae) ticks.Parasite (Paris, France) · 2019Article
- Metagenomic Analysis of Bacteria, Fungi, Bacteriophages, and Helminths in the Gut of Giant Pandas.Frontiers in microbiology · 2018Article
- Parasites of the Giant Panda: A Risk Factor in the Conservation of a Species.Advances in parasitology · 2018Review
- Cloning and characterization of a novel sigma-like glutathione S-transferase from the giant panda parasitic nematode, Baylisascaris schroederi.Parasites & vectors · 2015Article
- Absence of genetic structure in Baylisascaris schroederi populations, a giant panda parasite, determined by mitochondrial sequencing.Parasites & vectors · 2014Article
- Comparative analysis of microRNA profiles between adult Ascaris lumbricoides and Ascaris suum.BMC veterinary research · 2014Article
- Identification and characterization of the expression profile of microRNAs in Anopheles anthropophagus.Parasites & vectors · 2014Article
- Global characterization of microRNAs in Trichomonas gallinae.Parasites & vectors · 2014Article
- Analysis of the genetic diversity of the nematode parasite Baylisascaris schroederi from wild giant pandas in different mountain ranges in China.Parasites & vectors · 2013Article
- Expression of Mir-21 and Mir-103a inIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBaylisascaris schroederi is one of the most significant threats to the giant panda's survival, responsible for half of the deaths reported from 2001 to 2005. MicroRNA (miRNA) has been identified as one of the key factors for gene regulations at the post-transcriptional level, and also considered as a potential control and treatment target against infectious diseases.
methodsThe present study investigated the miRNA profile of B. schroederi via high throughput sequencing and real-time quantitative PCR.
resultsA total of 18.07 million raw reads were obtained and 18.01 million were identified with high quality. By analysis of standard stem-loop structures, 108 miRNA candidates were predicted, including 60 known miRNAs and 48 novel ones. Target prediction revealed that the "chitinase" was the most abundant target with 483 sequences, and 263 targets were related to ovarian and egg development. The ribosomal protein related sequences occupied 449 sequences.
conclusionsPrevious studies have shown that some parasites secrete chitinases for exsheathment and/or for penetrating the peritrophic matrix of the host. It therefore seems that B. schroederi may be effectively regulated by miRNAs for development, invasion, and reproduction. Given that chitinases have been identified as important biological control agents for pests, identification of microRNAs in B. schroederi of the giant panda would provide useful information for the development of biological control strategies and/or vaccines against B. schroederi infection in the giant panda.
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