Evidence map›Paper›PMID 23883525›Full record

Trial reportCritical care (London, England)2013

Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up.

Linda Denehy, Elizabeth H Skinner, Lara Edbrooke, Kimberley Haines, Stephen Warrillow, Graeme Hawthorne, Karla Gough, Steven Vander Hoorn, Meg E Morris, Sue Berney

3 registry-linked trialsAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 172 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 19 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02963558 nacompletednot on this mapstarted 2017, after this paper: background citation

ASPIRE: A Study Promoting Critical Illness Recovery in the Elderly

TypeinterventionalSponsorWake Forest University Health SciencesRan2017 to 2021Enrolled24ConditionsAcute Respiratory Distress Syndrome, Critical Illness, Critical CareArmscycle ergometry
NCT04556227 narecruitingnot on this mapstarted 2024, after this paper: background citation

Simultaneous Recumbent Cycling and Cognitive Training on Cognition in Intensive Care Unit Survivors: a Randomized Control Trial

TypeinterventionalSponsorUniversity of Missouri, Kansas CityRan2024 to 2025Enrolled50ConditionsDelirium, Impaired CognitionArmsSimultaneous Cycle/Cognitive Training
NCT04938531 nacompletednot on this mapstarted 2015, after this paper: background citation

Targeted Exercise Intervention to Reduce Morbidity and Mortality in Sepsis

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2015 to 2019Enrolled20ConditionsSevere SepsisArmsExercise
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 19 syntheses or guidelines pooled it.

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  17. Physical rehabilitation for critical illness myopathy and neuropathy.The Cochrane database of systematic reviews · 2015
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112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Linda Denehy
Elizabeth H Skinner
Lara Edbrooke
Kimberley Haines
Stephen Warrillow
Graeme Hawthorne
Karla Gough
Steven Vander Hoorn
Meg E Morris
Sue Berney

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this trial was to investigate the effectiveness of an exercise rehabilitation program commencing during ICU admission and continuing into the outpatient setting compared with usual care on physical function and health-related quality of life in ICU survivors.

methodsWe conducted a single-center, assessor-blinded, randomized controlled trial. One hundred and fifty participants were stratified and randomized to receive usual care or intervention if they were in the ICU for 5 days or more and had no permanent neurological insult. The intervention group received intensive exercises in the ICU and the ward and as outpatients. Participants were assessed at recruitment, ICU admission, hospital discharge and at 3-, 6- and 12-month follow-up. Physical function was evaluated using the Six-Minute Walk Test (6MWT) (primary outcome), the Timed Up and Go Test and the Physical Function in ICU Test. Patient-reported outcomes were measured using the Short Form 36 Health Survey, version 2 (SF-36v2) and Assessment of Quality of Life (AQoL) Instrument. Data were analyzed using mixed models.

resultsThe a priori enrollment goal was not reached. There were no between-group differences in demographic and hospital data, including acuity and length of acute hospital stay (LOS) (Acute Physiology and Chronic Health Evaluation II score: 21 vs 19; hospital LOS: 20 vs 24 days). No significant differences were found for the primary outcome of 6MWT or any other outcomes at 12 months after ICU discharge. However, exploratory analyses showed the rate of change over time and mean between-group differences in 6MWT from first assessment were greater in the intervention group.

conclusionsFurther research examining the trajectory of improvement with rehabilitation is warranted in this population.

trial registrationThe trial was registered with the Australian New Zealand Clinical Trials Registry ACTRN12605000776606.

Indexed as

Intensive Care UnitsQuality of LifeAdultAgedCritical IllnessExercise TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedRecovery of FunctionSingle-Blind Method

Identifiers

PMID23883525
PMCPMC4056792

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.