ArticleMolecular biology and evolution2013
Expression and sequence evolution of aromatase cyp19a1 and other sexual development genes in East African cichlid fishes.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 71 citations in OpenAlex.
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- Dynamics of sex chromosome evolution in a rapid radiation of cichlid fishes.Science advances · 2021Article
- Epigenetic mechanisms in sex determination and in the evolutionary transitions between sexual systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The divergence of alternative splicing between ohnologs in teleost fishes.BMC ecology and evolution · 2021Article
- Evolutionary divergence of novel open reading frames in cichlids speciation.Scientific reports · 2020Article
- Evolutionary diversity as a catalyst for biological discovery.Integrative zoology · 2018Review
- The transcriptomic signature of different sexes in two protogynous hermaphrodites: Insights into the molecular network underlying sex phenotype in fish.Scientific reports · 2018Article
- Sex-specific dmrt1 and cyp19a1 methylation and alternative splicing in gonads of the protandrous hermaphrodite barramundi.PloS one · 2018Article
- The Gene Toolkit Implicated in Functional Sex in Sparidae Hermaphrodites: Inferences From Comparative Transcriptomics.Frontiers in genetics · 2018Article
- Adaptive Evolution of Energy Metabolism-Related Genes in Hypoxia-Tolerant Mammals.Frontiers in genetics · 2017Article
- Variations on a theme: Genomics of sex determination in the cichlid fish Astatotilapia burtoni.BMC genomics · 2016Article
- Genomic identification, rapid evolution, and expression of Argonaute genes in the tilapia, Oreochromis niloticus.Development genes and evolution · 2016Article
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- Epigenetic regulation of sex ratios may explain natural variation in self-fertilization rates.Proceedings. Biological sciences · 2015Article
- Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).BMC genomics · 2015Article
- Large-scale transcriptome sequencing reveals novel expression patterns for key sex-related genes in a sex-changing fish.Biology of sex differences · 2015Article
- Variation in the ontogeny of sex steroid levels between latitudinal populations of the medaka.Zoological letters · 2015Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Sex determination mechanisms are highly variable across teleost fishes and sexual development is often plastic. Nevertheless, downstream factors establishing the two sexes are presumably conserved. Here, we study sequence evolution and gene expression of core genes of sexual development in a prime model system in evolutionary biology, the East African cichlid fishes. Using the available five cichlid genomes, we test for signs of positive selection in 28 genes including duplicates from the teleost whole-genome duplication, and examine the expression of these candidate genes in three cichlid species. We then focus on a particularly striking case, the A- and B-copies of the aromatase cyp19a1, and detect different evolutionary trajectories: cyp19a1A evolved under strong positive selection, whereas cyp19a1B remained conserved at the protein level, yet is subject to regulatory changes at its transcription start sites. Importantly, we find shifts in gene expression in both copies. Cyp19a1 is considered the most conserved ovary-factor in vertebrates, and in all teleosts investigated so far, cyp19a1A and cyp19a1B are expressed in ovaries and the brain, respectively. This is not the case in cichlids, where we find new expression patterns in two derived lineages: the A-copy gained a novel testis-function in the Ectodine lineage, whereas the B-copy is overexpressed in the testis of the speciest-richest cichlid group, the Haplochromini. This suggests that even key factors of sexual development, including the sex steroid pathway, are not conserved in fish, supporting the idea that flexibility in sexual determination and differentiation may be a driving force of speciation.
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