ArticleJournal of leukocyte biology2013
Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils.
Article in Journal of leukocyte biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Safety and efficacy of n-3 fatty acid-based parenteral nutrition in patients with obstructive jaundice: a propensity-matched study.European journal of clinical nutrition · 2018Trial
- Case Report: A steroid-sparing mechanical management of IgG4-related sclerosing cholangitis mimicking cholangiocarcinoma.Frontiers in immunology · 2026Article
- Emerging role of bile acids in colorectal liver metastasis: From molecular mechanism to clinical significance (Review).International journal of oncology · 2025Review
- Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects.EMBO molecular medicine · 2024Article
- The gut microbiota-bile acid axis in cholestatic liver disease.Molecular medicine (Cambridge, Mass.) · 2024Review
- Cholestasis-induced phenotypic transformation of neutrophils contributes to immune escape of colorectal cancer liver metastasis.Journal of biomedical science · 2024Article
- Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology.Nature reviews. Gastroenterology & hepatology · 2022Review
- Programmed cell death 1 positive lymphocytes at palate tonsils in the elder patients with chronic tonsillitis.Biochemistry and biophysics reports · 2021Article
- The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.Frontiers in pharmacology · 2019Article
- Preventive effect of artemisinin extract against cholestasis induced via lithocholic acid exposure.Bioscience reports · 2018Article
- Dietary and metabolic modulators of hepatic immunity.Seminars in immunopathology · 2018Review
- Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids.Scientific reports · 2018Article
- Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma.Clinical & translational immunology · 2017Review
- Mechanisms of bile acid mediated inflammation in the liver.Molecular aspects of medicine · 2017Review
- Improved survival after induction of sepsis by cecal slurry in PD-1 knockout murine neonates.Surgery · 2017Article
- Immunosuppression in liver tumors: opening the portal to effective immunotherapy.Cancer gene therapy · 2017Review
- The impact of sterile inflammation in acute liver injury.Journal of clinical and translational research · 2017Article
- Murine model of long-term obstructive jaundice.The Journal of surgical research · 2016Article
- Therapeutic targets for cholestatic liver injury.Expert opinion on therapeutic targets · 2016Review
- The Inflammatory Cytokine IL-21 is Expressed by Splenic Neutrophils in Response to Transplantation of Allogeneic Cells.SOJ immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Biliary obstruction is a common clinical problem that is associated with intrahepatic inflammation and impaired immunity. PD-1 is well known to mediate T cell dysfunction but has been reported to promote and attenuate acute inflammation in various injury models. With the use of a well-established murine model of BDL, we studied the effects of intrahepatic PD-1 expression on LTC function, inflammation, and cholestasis. Following BDL, PD-1 expression increased significantly among LTCs. Increased PD-1 expression following BDL was associated with decreased LTC proliferation and less IFN-γ production. Elimination of PD-1 expression resulted in significantly improved proliferative capacity among LTC following BDL, in addition to a more immunostimulatory cytokine profile. Not only was LTC function rescued in PD-1(-/-) mice, but also, the degrees of biliary cell injury, cholestasis, and inflammation were diminished significantly compared with WT animals following BDL. PD-1-mediated acute inflammation following BDL was associated with expansions of intrahepatic neutrophil and Th17 cell populations, with the latter dependent on IL-6. PD-1 blockade represents an attractive strategy for reversing intrahepatic immunosuppression while limiting inflammatory liver damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.