ArticleBMC immunology2013
Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein.
Article in BMC immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
- Camel Milk Alleviates Chronic Fatigue Syndrome-like Symptoms in Mice by Modulating the Small Intestinal Microbiota and Inflammation.Foods (Basel, Switzerland) · 2026Article
- Research on the mechanism of cow milk protein dietary intervention in ameliorating systemic chronic inflammation in type 2 diabetes by disrupting the ROS-M1 macrophage axis.Frontiers in nutrition · 2026Article
- A sprayable exosome-loaded hydrogel with controlled release and multifunctional synergistic effects for diabetic wound healing.Materials today. Bio · 2025Article
- Camel (Biology · 2025Review
- Correction to "Maternal Rat Diabetes Mellitus Deleteriously Affects Insulin Sensitivity and Beta-Cell Function in the Offspring".Journal of diabetes research · 2025Article
- Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies.ACS omega · 2024Review
- The Potential of Sheep or Camel Milk Constituents to Contribute to Novel Dressings for Diabetic Wounds.International journal of molecular sciences · 2023Review
- Multifunctional antibacterial bioactive nanoglass hydrogel for normal and MRSA infected wound repair.Journal of nanobiotechnology · 2023Article
- Ameliorative Effects of Camel Milk and Its Exosomes on Diabetic Nephropathy in Rats.Membranes · 2022Article
- The Antioxidant, Anti-Inflammatory and Immunomodulatory Effects of Camel Milk.Frontiers in immunology · 2022Review
- Article
- Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma.Scientific reports · 2021Article
- Camel milk as an alternative treatment regimen for diabetes therapy.Food science & nutrition · 2021Article
- Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.BioMed research international · 2020Article
- Samsum ant venom modulates the immune response and redox status at the acute toxic doseThe journal of venomous animals and toxins including tropical diseases · 2019Article
- From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products.Frontiers in genetics · 2019Review
- In Vitro Wound Healing Potential of Stem Extract ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Wound healing: time to look for intelligent, 'natural' immunological approaches?BMC immunology · 2017Review
- Why whey? Camel whey protein as a new dietary approach to the management of free radicals and for the treatment of different health disorders.Iranian journal of basic medical sciences · 2017Review
- Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum inophyllum Linn.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired diabetic wound healing occurs as a consequence of excessive reactive oxygen species (ROS) and inflammatory cytokine production. We previously found that whey protein (WP) was able to normally regulate the ROS and inflammatory cytokines during the inflammatory phase (first day) in streptozotocin (STZ)-diabetic wound healing. This study was designed to assess the effect of WP on metabolic status, the inflammation and anti-inflammation response, oxidative stress and the antioxidant defense system during different phases of the wound healing process in diabetic rats. WP at a dosage of 100 mg/kg of body weight, dissolved in 1% CMC, was orally administered daily to wounded normal (non-diabetic) and STZ-induced diabetic rats for 8 days starting from the 1st day after wounding.
resultsThe data revealed that WP enhanced wound closure and was associated with an increase in serum insulin levels in diabetic rats and an alleviation of hyperglycemic and hyperlipidemic states in diabetic animals. The increase in insulin levels as a result of WP administration is associated with a marked multiplication of β-cells in the core of islets of Langerhans. WP induced a reduction in serum TNF-α, IL-1β and IL-6 levels and an increase in IL-10 levels, especially on the 4th day after wounding and treatment. WP also suppressed hepatic lipid peroxidation and stimulated the antioxidant defense system by increasing the level of glutathione and the activity of glutathione-S-transferase, glutathione peroxidase and superoxide dismutase (SOD) in wounded diabetic rats.
conclusionsWP was observed to enhance wound closure by improving the diabetic condition, limiting prolonged inflammation, suppressing oxidative stress and elevating the antioxidant defense system in diabetic rats.
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