SynthesisBMC public health2013
Vitamin D and subsequent all-age and premature mortality: a systematic review.
Synthesis in BMC public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies.Nutrients · 2019Pooled it
- Regional Assessment of Temperature-Related Mortality in Finland.International journal of environmental research and public health · 2018Pooled it
- Effect of Single High Dose Vitamin D Administration in Critically Ill Vitamin D-deficient Pediatric Patients: A Randomized Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Article
- Meteorological Condition and Air Pollution Exposure Associated with Vitamin D Deficiency: A Cross-Sectional Population-Based Study in China.Risk management and healthcare policy · 2020Article
- Independent association between socioeconomic indicators and macro- and micro-nutrient intake in Switzerland.PloS one · 2017Article
- Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails.Journal of Alzheimer's disease : JAD · 2016Review
- The inverse association between serum 25-hydroxyvitamin D and mortality may be modified by vitamin A status and use of vitamin A supplements.European journal of nutrition · 2016Article
- Vitamin D in schizophrenia: a clinical review.Evidence-based mental health · 2016Review
- 25-hydroxyvitamin D and increased all-cause mortality in very old women: the Newcastle 85+ study.Journal of internal medicine · 2015Article
- Perspectives on differing health outcomes by city: accounting for Glasgow's excess mortality.Risk management and healthcare policy · 2015Review
- Serum 25-hydroxyvitamin D, mortality, and incident cardiovascular disease, respiratory disease, cancers, and fractures: a 13-y prospective population study.The American journal of clinical nutrition · 2014Article
- Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study.European journal of neurology · 2014Article
- Spatial inequalities in life expectancy within postindustrial regions of Europe: a cross-sectional observational study.BMJ open · 2014Observational
- Vitamin D activities for health outcomes.Annals of laboratory medicine · 2014Review
- Does vitamin D sufficiency equate to a single serum 25-hydroxyvitamin D level or are different levels required for non-skeletal diseases?Nutrients · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAll-cause mortality in the population<65 years is 30% higher in Glasgow than in equally deprived Liverpool and Manchester. We investigated a hypothesis that low vitamin D in this population may be associated with premature mortality via a systematic review and meta-analysis.
methodsMedline, EMBASE, Web of Science, the Cochrane Library and grey literature sources were searched until February 2012 for relevant studies. Summary statistics were combined in an age-stratified meta-analysis.
resultsNine studies were included in the meta-analysis, representing 24,297 participants, 5,324 of whom died during follow-up. The pooled hazard ratio for low compared to high vitamin D demonstrated a significant inverse association (HR 1.19, 95% CI 1.12-1.27) between vitamin D levels and all-cause mortality after adjustment for available confounders. In an age-stratified meta-analysis, the hazard ratio for older participants was 1.25 (95% CI 1.14-1.36) and for younger participants 1.12 (95% CI 1.01-1.24).
conclusionsLow vitamin D status is inversely associated with all-cause mortality but the risk is higher amongst older individuals and the relationship is prone to residual confounding. Further studies investigating the association between vitamin D deficiency and all-cause mortality in younger adults with adjustment for all important confounders (or using randomised trials of supplementation) are required to clarify this relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.