ArticleFrontiers in human neuroscience2013
Neural markers of errors as endophenotypes in neuropsychiatric disorders.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02801513 (Maintaining Mechanisms of Chronic Depression and Their Changeability), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maintaining Mechanisms of Chronic Depression and Their Changeability: the Role of Discrepancy-based Processing
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Attention bias modification reduces neural correlates of response monitoring.Biological psychology · 2017Trial
- Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism.NeuroImage. Clinical · 2016Trial
- Preserved Error-Monitoring in Borderline Personality Disorder Patients with and without Non-Suicidal Self-Injury Behaviors.PloS one · 2015Trial
- Blunted No-Go P3 predicts faster increases in disordered eating symptoms in early adolescents: A four-wave longitudinal study.Research square · 2026Article
- Context-tuned strategies for marker selection precision in neuronal studies.Frontiers in neuroscience · 2026Review
- The neurobehavioral correlates of error processing in adult attention-deficit/hyperactivity disorder and their relationship with impulsivity.Clinical neurophysiology practice · 2025Article
- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Behavioral and ERP indices of self-schematic processing show differential associations with emerging symptoms of depression and social anxiety in late childhood: Evidence from a community-dwelling sample.Biological psychology · 2023Article
- Neurophysiological mechanisms of error monitoring in human and non-human primates.Nature reviews. Neuroscience · 2023Review
- Associations between lifetime stress exposure and the error-related negativity (ERN) differ based on stressor characteristics and exposure timing in young adults.Cognitive, affective & behavioral neuroscience · 2022Article
- Neural signature of error processing in major depression.European archives of psychiatry and clinical neuroscience · 2021Article
- Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood.Clinical epigenetics · 2021Article
- Test-Retest Reliability of Neural Correlates of Response Inhibition and Error Monitoring: An fMRI Study of a Stop-Signal Task.Frontiers in neuroscience · 2021Article
- Depressogenic self-schemas are associated with smaller regional grey matter volume in never-depressed preadolescents.NeuroImage. Clinical · 2020Article
- Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors.Development and psychopathology · 2019Article
- Evidence for cerebello-thalamo-cortical hyperconnectivity as a heritable trait for schizophrenia.Translational psychiatry · 2019Article
- Error-related neural activity and alcohol use disorder: Differences from risk to remission.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder.Psychological medicine · 2019Article
- A neural biomarker, the error-related negativity, predicts the first onset of generalized anxiety disorder in a large sample of adolescent females.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Learning from errors is fundamental to adaptive human behavior. It requires detecting errors, evaluating what went wrong, and adjusting behavior accordingly. These dynamic adjustments are at the heart of behavioral flexibility and accumulating evidence suggests that deficient error processing contributes to maladaptively rigid and repetitive behavior in a range of neuropsychiatric disorders. Neuroimaging and electrophysiological studies reveal highly reliable neural markers of error processing. In this review, we evaluate the evidence that abnormalities in these neural markers can serve as sensitive endophenotypes of neuropsychiatric disorders. We describe the behavioral and neural hallmarks of error processing, their mediation by common genetic polymorphisms, and impairments in schizophrenia, obsessive-compulsive disorder, and autism spectrum disorders. We conclude that neural markers of errors meet several important criteria as endophenotypes including heritability, established neuroanatomical and neurochemical substrates, association with neuropsychiatric disorders, presence in syndromally-unaffected family members, and evidence of genetic mediation. Understanding the mechanisms of error processing deficits in neuropsychiatric disorders may provide novel neural and behavioral targets for treatment and sensitive surrogate markers of treatment response. Treating error processing deficits may improve functional outcome since error signals provide crucial information for flexible adaptation to changing environments. Given the dearth of effective interventions for cognitive deficits in neuropsychiatric disorders, this represents a potentially promising approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.