ArticleFrontiers in neuroscience2013
Characterization of the effects of oxytocin on fear recognition in patients with schizophrenia and in healthy controls.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Efficacy and safety of oxytocin augmentation therapy for schizophrenia: an updated systematic review and meta-analysis of randomized, placebo-controlled trials.European archives of psychiatry and clinical neuroscience · 2016Pooled it
- A randomized controlled trial of intranasal oxytocin in Phelan-McDermid syndrome.Molecular autism · 2021Trial
- Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity.Psychopharmacology · 2021Trial
- Oxytocin biases eye-gaze to dynamic and static social images and the eyes of fearful faces: associations with trait autism.Translational psychiatry · 2020Trial
- Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Oxytocin administration enhances controlled social cognition in patients with schizophrenia.Psychoneuroendocrinology · 2014Trial
- Oxytocin agonist TGOT differentially modulates synaptic plasticity and intrinsic excitability in a sex-specific manner in the juvenile rat hippocampus.Communications biology · 2026Article
- The Interplay of Oxytocin and Attachment in Schizophrenic Patients: An fMRI Study.Brain sciences · 2023Article
- Involvement of oxytocin receptor deficiency in psychiatric disorders and behavioral abnormalities.Frontiers in cellular neuroscience · 2023Review
- A Systematic Review of the Role of Oxytocin, Cortisol, and Testosterone in Facial Emotional Processing.Biology · 2021Review
- Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.International journal of molecular sciences · 2021Review
- The Effect of Intranasal Oxytocin on Measures of Social Cognition in Schizophrenia: A Negative Report.Journal of psychiatry and brain science · 2019Article
- First experiences with neuropsychological effects of oxytocin administration in childhood-onset craniopharyngioma.Endocrine · 2017Article
- Potential of Oxytocin in the Treatment of Schizophrenia.CNS drugs · 2016Review
- Sex and diagnosis specific associations between DNA methylation of the oxytocin receptor gene with emotion processing and temporal-limbic and prefrontal brain volumes in psychotic disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Oxytocin in the socioemotional brain: implications for psychiatric disorders.Dialogues in clinical neuroscience · 2015Review
- Plasma oxytocin levels predict social cue recognition in individuals with schizophrenia.Schizophrenia research · 2015Article
- Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia.Schizophrenia research · 2015Article
- Oxytocin and social cognition in affective and psychotic disorders.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Review
- Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals who suffer from schizophrenia often show a marked deficit in recognition of emotional facial expressions, as part of broader impairment of social cognition. Research has shown that recognition of negative emotions, specifically fear recognition, is particularly impaired among patients with schizophrenia. Recently we reported that intranasal administration of OT (IN OT) increased the ability to correctly recognize fear in a group of healthy men. The aim of the current study was to examine the effects of IN OT administration on fear recognition among patients with schizophrenia. Based on previous research, we also sought to examine a possible selective effect of OT dependent on baseline performance, hypothesizing that IN OT would have a greater enhancement effect on less proficient individuals. It was thus hypothesized that patients will show more improvement in fear recognition following the administration of IN OT as compared to controls. Sixty six participants (31 schizophrenia patients, 35 healthy controls) were enrolled in the current study. All participants received treatment of a single dose of 24 IU IN OT and an equivalent amount of placebo, 1 week apart. The participants' ability to accurately recognize fear and happiness was evaluated using a face morphing task. Overall, as a group, both patients and healthy control participants were more accurate in recognizing fearful facial expressions, but not happy faces, following IN OT administration, as compared to their performance following placebo. IN OT did not differentially affect emotion recognition in patients and healthy controls. Yet, the results indicated a selective effect for IN OT, in which the hormone improves fear recognition only among individuals whose baseline performance was below the median, regardless of their psychiatric status.
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