ArticleNutrition and metabolic insights2012
Plasma copper and zinc concentration in individuals with autism correlate with selected symptom severity.
Article in Nutrition and metabolic insights, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Plasma zinc, copper and serum ceruloplasmin levels of autism spectrum disorder children in Bangladesh.Heliyon · 2023Article
- Multivariate Analysis of Metabolomic and Nutritional Profiles among Children with Autism Spectrum Disorder.Journal of personalized medicine · 2022Article
- Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders.Cellular and molecular life sciences : CMLS · 2021Article
- Zinc.Advances in food and nutrition research · 2021Review
- Nutritional status in irritable bowel syndrome: A North American population-based study.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.Scientific reports · 2017Article
- Zinc and Copper Metabolism and Risk of Autism: a reply to Sayehmiri et al.Iranian journal of child neurology · 2017Article
- Severity of Autism Spectrum Disorders: Current Conceptualization, and Transition to DSM-5.Journal of autism and developmental disorders · 2016Article
- The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis.Iranian journal of child neurology · 2016Review
- Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency.Frontiers in behavioral neuroscience · 2016Article
- Nutritional status of individuals with autism spectrum disorders: do we know enough?Advances in nutrition (Bethesda, Md.) · 2015Review
- Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis.Iranian journal of child neurology · 2015Review
- Zinc in gut-brain interaction in autism and neurological disorders.Neural plasticity · 2015Review
- Behavioral impairments in animal models for zinc deficiency.Frontiers in behavioral neuroscience · 2014Review
- Article
Corrections and comments
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Authors and funding
23 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. SUBJECTS AND
methodsPlasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms.
resultsAutistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity. DISCUSSION: These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.