ArticleGenome biology and evolution2013
Recent recombination events in the core genome are associated with adaptive evolution in Enterococcus faecium.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed, 104 citations in OpenAlex.
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- Vancomycin-Resistant Enterococci: Current Understandings of Resistance in Relation to Transmission and Preventive Strategies.Pathogens (Basel, Switzerland) · 2024Review
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- A diverse set of Enterococcus-infecting phage provides insight into phage host-range determinants.Virus research · 2024Article
- Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy.BMC microbiology · 2024Review
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- Enterococcal Membrane Vesicles as Vaccine Candidates.International journal of molecular sciences · 2023Article
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- Exploring the mobilome and resistome ofMicrobial genomics · 2022Article
- Current Methods for Recombination Detection in Bacteria.International journal of molecular sciences · 2022Review
- The interplay between community and hospitalThe Lancet. Microbe · 2022Article
- Antimicrobial-Resistant Evolution and Global Spread ofChina CDC weekly · 2022Review
- Sugarcoating it: Enterococcal polysaccharides as key modulators of host-pathogen interactions.PLoS pathogens · 2021Review
- Lytic bacteriophages facilitate antibiotic sensitization ofAntimicrobial agents and chemotherapy · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reasons for the rising clinical impact of the bacterium Enterococcus faecium include the species' rapid acquisition of adaptive genetic elements. Here, we focused on the impact of recombination on the evolution of E. faecium. We used the recently developed BratNextGen algorithm to detect recombinant regions in the core genome of 34 E. faecium strains, including three newly sequenced clinical strains. Recombination was found to have a significant impact on the E. faecium genome: of the original 1.2 million positions in the core genome, 0.5 million were predicted to have been affected by recombination in at least one strain. Importantly, strains in one of the two major E. faecium clades (clade B), which contains most of the E. faecium human gut commensals, formed the most important reservoir for donating foreign DNA to the second major E. faecium clade (clade A), which contains most of the clinical isolates. Also, several genomic regions were found to mainly recombine in specific hospital-associated E. faecium strains. One of these regions (the epa-like locus) likely encodes the biosynthesis of cell wall polysaccharides. These findings suggest a crucial role for recombination in the emergence of E. faecium as a successful hospital-associated pathogen.
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