ArticleRNA (New York, N.Y.)2013
The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution.
Article in RNA (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- MicroRNAs as potential biomarkers for monitoring of acquired sensorineural hearing loss.Pediatric discovery · 2024Review
- Parameters of clustered suboptimal miRNA biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine.Cell genomics · 2023Article
- Elucidation of the MicroRNA Transcriptome in Western Corn Rootworm Reveals Its Dynamic and Evolutionary Complexity.Genomics, proteomics & bioinformatics · 2021Article
- Splice and Dice: Intronic microRNAs, Splicing and Cancer.Biomedicines · 2021Review
- Run or Die in the Evolution of New MicroRNAs-Testing the Red Queen Hypothesis on De Novo New Genes.Molecular biology and evolution · 2021Article
- Cloning and characterization of Bubaline mammary miRNAs: An in silico approach.Molecular biology reports · 2019Article
- Predicting microRNA targeting efficacy in Drosophila.Genome biology · 2018Article
- Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation duringeLife · 2018Article
- MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution.RNA (New York, N.Y.) · 2018Article
- On the possibility of death of new genes - evidence from the deletion of de novo microRNAs.BMC genomics · 2018Article
- Regulation of Large Number of Weak Targets-New Insights from Twin-microRNAs.Genome biology and evolution · 2018Article
- Deep experimental profiling of microRNA diversity, deployment, and evolution across theGenome research · 2018Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site.Cell reports · 2016Article
- Splicing-dependent expression of microRNAs of mirtron origin in human digestive and excretory system cancer cells.Clinical epigenetics · 2016Article
- Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor.Molecular cell · 2015Article
- Evolutionary Comparison of Two Combinatorial Regulators of SBP-Box Genes, MiR156 and MiR529, in Plants.PloS one · 2015Article
- Diverse modes of evolutionary emergence and flux of conserved microRNA clusters.RNA (New York, N.Y.) · 2014Article
- Microevolution of nematode miRNAs reveals diverse modes of selection.Genome biology and evolution · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The molecular evolutionary signatures of miRNAs inform our understanding of their emergence, biogenesis, and function. The known signatures of miRNA evolution have derived mostly from the analysis of deeply conserved, canonical loci. In this study, we examine the impact of age, biogenesis pathway, and genomic arrangement on the evolutionary properties of Drosophila miRNAs. Crucial to the accuracy of our results was our curation of high-quality miRNA alignments, which included nearly 150 corrections to ortholog calls and nucleotide sequences of the global 12-way Drosophilid alignments currently available. Using these data, we studied primary sequence conservation, normalized free-energy values, and types of structure-preserving substitutions. We expand upon common miRNA evolutionary patterns that reflect fundamental features of miRNAs that are under functional selection. We observe that melanogaster-subgroup-specific miRNAs, although recently emerged and rapidly evolving, nonetheless exhibit evolutionary signatures that are similar to well-conserved miRNAs and distinct from other structured noncoding RNAs and bulk conserved non-miRNA hairpins. This provides evidence that even young miRNAs may be selected for regulatory activities. More strikingly, we observe that mirtrons and clustered miRNAs both exhibit distinct evolutionary properties relative to solo, well-conserved miRNAs, even after controlling for sequence depth. These studies highlight the previously unappreciated impact of biogenesis strategy and genomic location on the evolutionary dynamics of miRNAs, and affirm that miRNAs do not evolve as a unitary class.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.