ReviewDrugs2013
Extra-esophageal manifestations of gastroesophageal reflux disease: diagnosis and treatment.
Review in Drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Pooled it
- A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2020Pooled it
- Evaluating the long-term efficacy of robotic anti-reflux surgery on symptom resolution in gerd patients: a comprehensive analysis of typical and atypical presentations.Surgical endoscopy · 2025Article
- Negative emotions mediate the causal association between GERD and MG: A mediation Mendelian randomization study.Medicine · 2025Article
- Article
- Natural Products in the Management of Gastroesophageal Reflux Disease: Mechanisms, Efficacy, and Future Directions.Nutrients · 2025Review
- Impact of medication use on olfactory performance in older adults.Frontiers in public health · 2025Observational
- Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor: A Pilot Study on Comparable Efficacy in the Treatment of Gastroesophageal Reflux-Related Cough.Allergy, asthma & immunology research · 2024Article
- Article
- Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study.BMC pulmonary medicine · 2023Article
- Revision paraesophageal hernia repair outcomes in patients with typical and atypical reflux.Surgical endoscopy · 2023Article
- Atopic dermatitis and risk of gastroesophageal reflux disease: A nationwide population-based study.PloS one · 2023Article
- Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy: A review.Medicine · 2022Review
- Videolaryngoscopy Findings of the Vocal Health Program in Dysphonic Teachers in the Federal District, Brazil.International archives of otorhinolaryngology · 2022Article
- An epidemiological survey of gastroesophageal reflux disease at the digestive endoscopy center in Guangzhou.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Gastrointestinal function testing model using a new laryngopharyngeal pH probe (Restech) in patients after Ivor-Lewis esophagectomy.World journal of gastrointestinal oncology · 2021Article
- Laryngopharyngeal pH Monitoring in Patients With Idiopathic Pulmonary Fibrosis.Frontiers in pharmacology · 2021Article
- The effect of adding duloxetine to lansoprazole on symptom and quality of life improvement in patients with gastroesophageal reflux diseases: A randomized double-blind clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Upper Endoscopy in Patients with Extra-Oesophageal Reflux Symptoms: A Multicentre Study.GE Portuguese journal of gastroenterology · 2020Article
- Laryngeal polyp associated with reflux disease: a case report.Journal of medical case reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is a common disease that is often diagnosed based on typical symptoms of heartburn and regurgitation. In addition to these more classic manifestations, GERD is increasingly associated with extra-esophageal symptoms, including chronic cough, asthma, laryngitis, and dental erosions. Due to the poor sensitivity of endoscopy and pH monitoring, and the poor specificity of laryngoscopy, empiric therapy with proton pump inhibitors (PPIs) is now considered the initial diagnostic step in patients suspected of having GERD-related symptoms. For those who improve with PPIs, GERD is the presumed etiology, but for those who remain unresponsive to such therapy, further diagnostic testing with impedance/pH monitoring may be necessary in order to exclude refractory acid or weakly acid reflux. In those with normal test results despite PPI therapy and continued symptoms, causes other than GERD may be pursued. Recent data suggest that in patients with extra-esophageal symptoms, objective findings of moderate-sized hiatal hernia and moderate reflux on pH testing may predict response to acid suppressive therapy. PPI-unresponsive patients usually have causes other than GERD for their extra-esophageal symptoms and continued PPI therapy in this group is not recommended.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.