ArticleNature chemistry2013
The Janus-faced role of external forces in mechanochemical disulfide bond cleavage.
Article in Nature chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 99 citations in OpenAlex.
- Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control.Journal of the American Chemical Society · 2025Article
- Structural analysis of a ligand-triggered intermolecular disulfide switch in a major latex protein from opium poppy.Acta crystallographica. Section D, Structural biology · 2024Article
- The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa.Journal of bacteriology · 2022Review
- High-pressure Nucleation of Low-Density Polymorphs*.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Mechanochemical bond scission for the activation of drugs.Nature chemistry · 2021Article
- Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release.Chemical science · 2020Article
- Force-conductance spectroscopy of a single-molecule reaction.Chemical science · 2019Article
- n→π* Interactions Modulate the Properties of Cysteine Residues and Disulfide Bonds in Proteins.Journal of the American Chemical Society · 2018Article
- Forcing the reversibility of a mechanochemical reaction.Nature communications · 2018Article
- Nucleophilic Substitution (SChemphyschem : a European journal of chemical physics and physical chemistry · 2018Review
- Article
- Tailoring protein nanomechanics with chemical reactivity.Nature communications · 2017Article
- Theoretical simulation of the infrared signature of mechanically stressed polymer solids.Beilstein journal of organic chemistry · 2017Article
- Mechanical gating of a mechanochemical reaction cascade.Nature communications · 2016Article
- De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds.Journal of the American Chemical Society · 2016Article
- Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding.Nature communications · 2016Article
- Release of Entropic Spring Reveals Conformational Coupling Mechanism in the ABC Transporter BtuCD-F.Biophysical journal · 2016Article
- Differences in the Abilities to Mechanically Eliminate Activation Energies for Unimolecular and Bimolecular Reactions.Scientific reports · 2016Article
- Validation of a Janus role of methotrexate-based PEGylated chitosan nanoparticles in vitro.Nanoscale research letters · 2014Article
- The effect of tensile stress on the conformational free energy landscape of disulfide bonds.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent force microscopy measurements on the mechanically activated cleavage of a protein disulfide bond through reaction with hydroxide ions revealed that for forces greater than 0.5 nN, the acceleration of the reaction rate is substantially reduced. Here, using ab initio simulations, we trace this 'reactivity switch' back to a dual role played by the mechanical force, which leads to antagonistic effects. On the one hand, the force performs work on the system, and thereby accelerates the reaction. On the other hand, the force also induces a conformational distortion that involves the S-S-C-C dihedral angle, which drives the disulfide into a conformation that is shielded against nucleophilic attack because of steric hindrance. The discovery of force-induced conformational changes that steer chemical reactivity provides a new key concept that is expected to be relevant beyond this specific case, for example in understanding how 'disulfide switches' regulate protein function and for the rational design of mechanoresponsive materials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.