Evidence map›Paper›PMID 23881465›Full record

SynthesisPlant foods for human nutrition (Dordrecht, Netherlands)2013

Dietary antioxidants, cognitive function and dementia--a systematic review.

Georgina E Crichton, Janet Bryan, Karen J Murphy

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Plant foods for human nutrition (Dordrecht, Netherlands), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 10 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 10 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Lycopene and cognitive function.Journal of nutritional science · 2019
    Pooled it
  6. Pooled it
  7. Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017
    Pooled it
  8. Vitamin E for Alzheimer's dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2017
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Article
  13. Neuroprotection of fermented small black soybean (Food science and biotechnology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Georgina E CrichtonNutritional Physiology Research Centre, University of South Australia, Adelaide, Australia.
Janet Bryan
Karen J Murphy
University of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antioxidant compounds, contained in fruit, vegetables and tea, have been postulated to have a protective effect against age-related cognitive decline by combating oxidative stress. However, recent research on this subject has been conflicting. The aim of this systematic review was to consider current epidemiological and longitudinal evidence for an association between habitual dietary intake of antioxidants and cognition, with consideration given to both cognitive functioning and risk for dementia and its subtypes, including Alzheimer's disease and vascular dementia. Searches of electronic databases were undertaken to identify peer-reviewed journal articles that reported on associations between antioxidant intakes (vitamins C, E, flavonoids, carotenoids) and cognitive function or risk for dementia. Eight cross-sectional and 13 longitudinal studies were identified and included in the review. There were mixed findings for the association between antioxidant intake, cognition and risk of dementia and Alzheimer's disease. Large heterogeneity in study design, differential control of confounders, insufficient measures of cognitive performance, and difficulties associated with dietary assessment may contribute to the inconsistent findings. Overall, findings do not consistently show habitual intakes of dietary antioxidants are associated with better cognitive performance or a reduced risk for dementia. Future intervention trials are warranted to elucidate the effects of a high intake of dietary antioxidants on cognitive functioning, and to explore effects within a whole dietary pattern.

Indexed as

DementiaDietAlzheimer DiseaseAntioxidantsAscorbic AcidCarotenoidsCognitionCross-Sectional StudiesDementia, VascularFemaleFlavonoidsHumansLongitudinal StudiesMaleMEDLINERisk FactorsAntioxidantsAscorbic AcidCarotenoidsFlavonoidsVitamin E

Identifiers

PMID23881465
OpenAlexW2014536978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.