ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2013
Epigenetic regulation of axon outgrowth and regeneration in CNS injury: the first steps forward.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Microfluidic Manipulation for Biomedical Applications in the Central and Peripheral Nervous Systems.Pharmaceutics · 2023Review
- Article
- Experimental Model Systems for Understanding Human Axonal Injury Responses.International journal of molecular sciences · 2021Review
- ARF6 and Rab11 as intrinsic regulators of axon regeneration.Small GTPases · 2020Review
- Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury.Neural regeneration research · 2020Review
- The stem cell markerProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment.Journal of cell science · 2017Article
- Mechanisms of Axonal Damage and Repair after Central Nervous System Injury.Translational stroke research · 2017Review
- The expression of histone deacetylases and the regenerative abilities of spinal-projecting neurons after injury.Neural regeneration research · 2016Article
- Bromodomains: Translating the words of lysine acetylation into myelin injury and repair.Neuroscience letters · 2016Review
- Extrinsic and intrinsic mechanisms of axon regeneration: the need for spinal cord injury treatment strategies to address both.Neural regeneration research · 2016Article
- Molecular and Cellular Mechanisms of Axonal Regeneration After Spinal Cord Injury.Molecular & cellular proteomics : MCP · 2016Review
- RegenBase: a knowledge base of spinal cord injury biology for translational research.Database : the journal of biological databases and curation · 2016Article
- Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons.Journal of neuroscience research · 2015Article
- Spinal cord injury and the neuron-intrinsic regeneration-associated gene program.Neuromolecular medicine · 2014Article
- Reshaping the chromatin landscape after spinal cord injury.Frontiers in biology · 2014Article
- Cell intrinsic control of axon regeneration.EMBO reports · 2014Review
- Axon-soma communication in neuronal injury.Nature reviews. Neuroscience · 2014Review
- The epigenetics of stroke recovery and rehabilitation: from polycomb to histone deacetylases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inadequate axonal sprouting and lack of regeneration limit functional recovery following neurologic injury, such as stroke, brain, and traumatic spinal cord injury. Recently, the enhancement of the neuronal regenerative program has led to promising improvements in axonal sprouting and regeneration in animal models of axonal injury. However, precise knowledge of the essential molecular determinants of this regenerative program remains elusive, thus limiting the choice of fully effective therapeutic strategies. Given that molecular regulation of axonal outgrowth and regeneration requires carefully orchestrated waves of gene expression, both temporally and spatially, epigenetic changes may be an ideal regulatory mechanism to address this unique need. While recent evidence suggests that epigenetic modifications could contribute to the regulation of axonal outgrowth and regeneration following axonal injury in models of stroke, and spinal cord and optic nerve injury, a number of unanswered questions remain. Such questions require systematic investigation of the epigenetic landscape between regenerative and non-regenerative conditions for the potential translation of this knowledge into regenerative strategies in human spinal and brain injury, as well as stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.