ArticleJournal of experimental botany2013
Deletion of chloroplast NADPH-dependent thioredoxin reductase results in inability to regulate starch synthesis and causes stunted growth under short-day photoperiods.
Article in Journal of experimental botany, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 80 citations in OpenAlex.
- Functional relationship of atypical thioredoxins with NADPH-thioredoxin reductase C and 2-Cys peroxiredoxins in Arabidopsis chloroplasts.Journal of experimental botany · 2025Article
- The impact of light and thioredoxins on the plant thiol-disulfide proteome.Plant physiology · 2024Article
- Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases.Redox biology · 2024Review
- Calredoxin regulates the chloroplast NADPH-dependent thioredoxin reductase in Chlamydomonas reinhardtii.Plant physiology · 2023Article
- Current Insights into the Redox Regulation Network in Plant Chloroplasts.Plant & cell physiology · 2023Review
- Chlamydomonas mutants lacking chloroplast TRIOSE PHOSPHATE TRANSPORTER3 are metabolically compromised and light sensitive.The Plant cell · 2023Article
- New Horizons in Plant Photoperiodism.Annual review of plant biology · 2023Review
- The Functional Relationship between NADPH Thioredoxin Reductase C, 2-Cys Peroxiredoxins, andAntioxidants (Basel, Switzerland) · 2023Article
- NewAntioxidants (Basel, Switzerland) · 2022Article
- Structure, function, and evolution of plant ADP-glucose pyrophosphorylase.Plant molecular biology · 2022Review
- A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control.Plant physiology · 2021Article
- Barley stripe mosaic virus γb protein disrupts chloroplast antioxidant defenses to optimize viral replication.The EMBO journal · 2021Article
- Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein.PLoS pathogens · 2021Article
- NTRC Effects on Non-Photochemical Quenching Depends on PGR5.Antioxidants (Basel, Switzerland) · 2021Article
- Redox regulation of chloroplast metabolism.Plant physiology · 2021Review
- NTRC and Thioredoxin f Overexpression Differentially Induces Starch Accumulation in Tobacco Leaves.Plants (Basel, Switzerland) · 2019Article
- NTRC Plays a Crucial Role in Starch Metabolism, Redox Balance, and Tomato Fruit Growth.Plant physiology · 2019Article
- Insights into the function of NADPH thioredoxin reductase C (NTRC) based on identification of NTRC-interacting proteins in vivo.Journal of experimental botany · 2019Article
- Chloroplast thioredoxin systems dynamically regulate photosynthesis in plants.The Biochemical journal · 2019Review
- Chloroplast Redox Regulatory Mechanisms in Plant Adaptation to Light and Darkness.Frontiers in plant science · 2019Review
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plastid-localized NADPH-dependent thioredoxin reductase C (NTRC) is a unique NTR enzyme containing both reductase and thioredoxin domains in a single polypeptide. Arabidopsis thaliana NTRC knockout lines (ntrc) show retarded growth, especially under short-day (SD) photoperiods. This study identified chloroplast processes that accounted for growth reduction in SD-acclimated ntrc. The strongest reduction in ntrc growth occurred under photoperiods with nights longer than 14 h, whereas knockout of the NTRC gene did not alter the circadian-clock-controlled growth of Arabidopsis. Lack of NTRC modulated chloroplast reactive oxygen species (ROS) metabolism, but oxidative stress was not the primary cause of retarded growth of SD-acclimated ntrc. Scarcity of starch accumulation made ntrc leaves particularly vulnerable to photoperiods with long nights. Direct interaction of NTRC and ADP-glucose pyrophosphorylase, a key enzyme in starch synthesis, was confirmed by yeast two-hybrid analysis. The ntrc line was not able to maximize starch synthesis during the light period, which was particularly detrimental under SD conditions. Acclimation of Arabidopsis to SD conditions also involved an inductive rise of ROS production in illuminated chloroplasts that was not counterbalanced by the activation of plastidial anti-oxidative systems. It is proposed that knockout of NTRC challenges redox regulation of starch synthesis, resulting in stunted growth of the mutant lines acclimated to the SD photoperiod.
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