ArticleViruses2013
Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis.
Article in Viruses, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- An evolutionarily conserved constellation of functional cis-elements programs the virus-responsive fate of the human (epi)genome.Nucleic acids research · 2025Article
- Review
- Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms.Nature communications · 2023Article
- Article
- Interleukins, Chemokines, and Tumor Necrosis Factor Superfamily Ligands in the Pathogenesis of West Nile Virus Infection.Viruses · 2023Review
- In-Depth Analysis of Genetic Variation Associated with Severe West Nile Viral Disease.Vaccines · 2020Article
- Article
- Transcriptional response to West Nile virus infection in the zebra finch (Royal Society open science · 2017Article
- Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis.Scientific reports · 2016Article
- Systems immunology reveals markers of susceptibility to West Nile virus infection.Clinical and vaccine immunology : CVI · 2015Article
- Power analysis and sample size estimation for RNA-Seq differential expression.RNA (New York, N.Y.) · 2014Article
- Multiplexed digital mRNA profiling of the inflammatory response in the West Nile Swiss Webster mouse model.PLoS neglected tropical diseases · 2014Article
- Detecting specific infections in children through host responses: a paradigm shift.Current opinion in infectious diseases · 2014Review
- Immune markers associated with host susceptibility to infection with West Nile virus.Viral immunology · 2014Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
The West Nile virus (WNV) is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophages of 10 healthy donors infected in vitro with WNV. From a total of 28 million reads per sample, we identified 1,514 transcripts that were differentially expressed after infection. Both predicted and novel gene changes were detected, as were gene isoforms, and while many of the genes were expressed by all donors, some were unique. Knock-down of genes not previously known to be associated with WNV resistance identified their critical role in control of viral infection. Our study distinguishes both common gene pathways as well as novel cellular responses. Such analyses will be valuable for translational studies of susceptible and resistant individuals--and for targeting therapeutics--in multiple biological settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.