Evidence map›Paper›PMID 23881189›Full record

ReviewDiabetes2013

Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?

Joshua P Thaler, Stephan J Guyenet, Mauricio D Dorfman, Brent E Wisse, Michael W Schwartz

Abstract readReview
In one paragraph

Review in Diabetes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  18. [Biomolecules · 2023
    Article
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41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joshua P ThalerDiabetes and Obesity Center of Excellence and Division of Metabolism, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Stephan J Guyenet
Mauricio D Dorfman
Brent E Wisse
Michael W Schwartz

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Tomas Vaisar · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE · 1986 to 2026
$30.4M
Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON, KRISTINA Marie UTZSCHNEIDER · 1986 to 2026
$10.0M
Novel Brain Mechanisms Controlling Glucose HomeostasisR01DK083042 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2008 to 2025
$7.6M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
NEUROENDOCRINE REGULATION OF ENERGY BALANCER01DK052989 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 1997 to 2011
$3.3M
Hypothalamic Inflammation and Energy HomeostasisR01DK090320 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHWARTZ, MICHAEL W · 2010 to 2014
$1.8M
Cellular Mechanisms of Hypothalamic Inflammation in High Fat Diet-Induced ObesityK08DK088872 · NIDDK · UNIVERSITY OF WASHINGTON · PI THALER, JOSHUA P · 2010 to 2014
$746k
The Role of Hypothalamic Superoxide in the Pathogenesis of Diet-Induced ObesityF32DK091989 · NIDDK · UNIVERSITY OF WASHINGTON · PI GUYENET, STEPHAN J. · 2011 to 2012
$70k
NHLBI NIH HHS T32 HL007028NIDDK NIH HHS DK052989NIDDK NIH HHS DK083042NIDDK NIH HHS DK088872NIDDK NIH HHS DK090320NIDDK NIH HHS F32 DK091989NIDDK NIH HHS F32DK091989NIDDK NIH HHS K08 DK088872NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK052989NIDDK NIH HHS R01 DK083042NIDDK NIH HHS R01 DK090320NIDDK NIH HHS T32 DK007247NIDDK NIH HHS T32DK007247
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsEnergy MetabolismHumansHypothalamusInflammationObesity

Identifiers

PMID23881189
PMCPMC3717869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.