ArticleAnnals of biomedical engineering2014
PEG-maleimide hydrogels for protein and cell delivery in regenerative medicine.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Coordination chemistry-enabled drug delivery systems: metal-ligand platforms for controlled release and targeted therapeutics.Journal of nanobiotechnology · 2026Review
- The Intersecting Physical Mechanisms That Regulate Cell Viability in 3D Synthetic Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Hydrogels in Cardiac Surgery: Versatile Platforms for Tissue Repair, Adhesion Prevention, and Localized Therapeutics.Gels (Basel, Switzerland) · 2025Review
- Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene.Bone research · 2024Article
- Mind the Viscous Modulus: The Mechanotransductive Response to the Viscous Nature of Isoelastic Matrices Regulates Stem Cell Chondrogenesis.Advanced healthcare materials · 2024Article
- Extracellular vesicle biopotentiated hydrogels for diabetic wound healing: The art of living nanomaterials combined with soft scaffolds.Materials today. Bio · 2023Review
- Hydrogel degradation promotes angiogenic and regenerative potential of cell spheroids for wound healing.Materials today. Bio · 2023Article
- Regulating the Homogeneity of Thiol-Maleimide Michael-Type Addition-Based Hydrogels Using Amino Biomolecules.Gels (Basel, Switzerland) · 2021Article
- Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels.Gels (Basel, Switzerland) · 2021Review
- Engineering hydrogels with homogeneous mechanical properties for controlling stem cell lineage specification.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties.Chemical reviews · 2021Review
- Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Large three-dimensional cell constructs for tissue engineering.Science and technology of advanced materials · 2021Review
- Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes.Stem cell reports · 2020Article
- Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment.Acta biomaterialia · 2019Article
- A rapid method for determining protein diffusion through hydrogels for regenerative medicine applications.APL bioengineering · 2018Article
- Control of thiol-maleimide reaction kinetics in PEG hydrogel networks.Acta biomaterialia · 2018Article
- Controlled JAGGED1 delivery induces human embryonic palate mesenchymal cells to form osteoblasts.Journal of biomedical materials research. Part A · 2018Article
- One step fabrication of hydrogel microcapsules with hollow core for assembly and cultivation of hepatocyte spheroids.Acta biomaterialia · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Protein- and cell-based therapies represent highly promising strategies for regenerative medicine, immunotherapy, and oncology. However, these therapies are significantly limited by delivery considerations, particularly in terms of protein stability and dosing kinetics as well as cell survival, engraftment, and function. Hydrogels represent versatile and robust delivery vehicles for proteins and cells due to their high water content that retains protein biological activity, high cytocompatibility and minimal adverse host reactions, flexibility and tunability in terms of chemistry, structure, and polymerization format, ability to incorporate various biomolecules to convey biofunctionality, and opportunity for minimally invasive delivery as injectable carriers. This review highlights recent progress in the engineering of poly(ethylene glycol) hydrogels cross-linked using maleimide reactive groups for protein and cell delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.