ReviewMolecules (Basel, Switzerland)2013
Recent trends in bioorthogonal click-radiolabeling reactions using fluorine-18.
Review in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 83 citations in OpenAlex.
- Deoxyfluorination of phenols for chemoselectiveNature protocols · 2023Review
- Radiochemistry for positron emission tomography.Nature communications · 2023Review
- Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023Review
- Recent Advances in the Development of Tetrazine Ligation Tools for Pretargeted Nuclear Imaging.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Strategic Evaluation of the Traceless Staudinger Ligation for Radiolabeling with the Tricarbonyl Core.Molecules (Basel, Switzerland) · 2021Article
- Bioorthogonal Reactions of Triarylphosphines and Related Analogues.Chemical reviews · 2021Review
- Synthesis of the Novel ATACS omega · 2020Article
- Small Molecule Sensors Targeting the Bacterial Cell Wall.ACS infectious diseases · 2020Review
- Kitamura Electrophilic Fluorination Using HF as a Source of Fluorine.Molecules (Basel, Switzerland) · 2020Review
- Synthesis and Evaluation of [Molecules (Basel, Switzerland) · 2020Article
- Synthesis and validation of [EJNMMI radiopharmacy and chemistry · 2020Article
- Aligning physics and physiology: Engineering antibodies for radionuclide delivery.Journal of labelled compounds & radiopharmaceuticals · 2018Review
- Hypervalent aryliodine compounds as precursors for radiofluorination.Journal of labelled compounds & radiopharmaceuticals · 2018Review
- Convenient Preparation ofPharmaceuticals (Basel, Switzerland) · 2017Article
- Review
- Synthesis of [Angewandte Chemie (International ed. in English) · 2017Article
- Click Chemistry and Radiochemistry: The First 10 Years.Bioconjugate chemistry · 2016Review
- Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer,EJNMMI research · 2016Article
- Synthesis, dynamic NMR characterization and XRD studies of novelBeilstein journal of organic chemistry · 2016Article
- Small Molecule Radiopharmaceuticals - A Review of Current Approaches.Frontiers in medicine · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing application of positron emission tomography (PET) in nuclear medicine has stimulated the extensive development of a multitude of novel and versatile bioorthogonal conjugation techniques especially for the radiolabeling of biologically active high molecular weight compounds like peptides, proteins or antibodies. Taking into consideration that the introduction of fluorine-18 (t(1/2) = 109.8 min) proceeds under harsh conditions, radiolabeling of these biologically active molecules represents an outstanding challenge and is of enormous interest. Special attention has to be paid to the method of 18F-introduction. It should proceed in a regioselective manner under mild physiological conditions, in an acceptable time span, with high yields and high specific activities. For these reasons and due to the high number of functional groups found in these compounds, a specific labeling procedure has to be developed for every bioactive macromolecule. Bioorthogonal strategies including the Cu-assisted Huisgen cycloaddition and its copper-free click variant, both Staudinger Ligations or the tetrazine-click reaction have been successfully applied and represent valuable alternatives for the selective introduction of fluorine-18 to overcome the afore mentioned obstacles. This comprehensive review deals with the progress and illustrates the latest developments in the field of bioorthogonal labeling with the focus on the preparation of radiofluorinated building blocks and tracers for molecular imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.