ReviewInternational journal of molecular sciences2013
Modulation of phytoalexin biosynthesis in engineered plants for disease resistance.
Review in International journal of molecular sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- PmWRKY-10 Enhances Pine Wilt Disease Resistance by Promoting Pinosylvin Monomethyl Ether Biosynthesis Through Transcriptional Activation of PmPMT2-1.Molecular plant pathology · 2026Article
- Ectopic Expression ofCurrent issues in molecular biology · 2026Article
- An In Silico Study of Resveratrol Derivatives as Dual Inhibitors of Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) in Cancer Therapy.Biotechnology and applied biochemistry · 2026Article
- Unveiling Dynamic Defense Pathways: Transcriptome Analysis of Phenylpropanoids and (Iso)flavonoids in Cowpea Leaves Post-CABMV Inoculation.Biochemical genetics · 2026Article
- Resveratrol supplementation as a non-surgical treatment in periodontitis and related systemic conditions.Journal of traditional and complementary medicine · 2026Review
- The resveratrol monomer enhances resistance to bacterial pathogen through the activation of SA-NPR1 signaling pathway inFrontiers in plant science · 2026Article
- The Phytochemical Composition and Molecular Mechanisms Involved in the Wound Healing Attributes ofPlants (Basel, Switzerland) · 2025Review
- Identification of a novel screening strategy of rice resistance breeding through phytoalexin content.Planta · 2025Article
- An Efficient Method for the Synthesis and In Silico Study of Novel Oxy-Camalexins.Molecules (Basel, Switzerland) · 2025Article
- Metabolomics Provides New Insights into the Mechanisms ofMicroorganisms · 2025Article
- Screening of soybean antifungal isoflavones based on targeted metabolomics analysis.Food chemistry: X · 2025Article
- Unraveling the Impact ofFoods (Basel, Switzerland) · 2024Article
- Genes to specialized metabolites: accumulation of scopoletin, umbelliferone and their glycosides in natural populations of Arabidopsis thaliana.BMC plant biology · 2024Article
- Multi-omics revealed molecular mechanism of biphenyl phytoalexin formation in response to yeast extract-induced oxidative stress in Sorbus aucuparia suspension cells.Plant cell reports · 2024Article
- Searching for the Virulence-contributing Genes of thePathogens (Basel, Switzerland) · 2024Article
- Ectopic overexpression ofFrontiers in plant science · 2024Article
- Plant Secondary Metabolites: The Weapons for Biotic Stress Management.Metabolites · 2023Review
- Pterostilbene in the treatment of inflammatory and oncological diseases.Frontiers in pharmacology · 2023Review
- Plant and pathogen genomics: essential approaches for stem rust resistance gene stacks in wheat.Frontiers in plant science · 2023Review
- Camalexin accumulation as a component of plant immunity during interactions with pathogens and beneficial microbes.Planta · 2022Review
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. Starting in the 1950's, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their structure, their biological activity as well as mechanisms of their synthesis and their catabolism by microorganisms. Elucidation of the biosynthesis of numerous phytoalexins has permitted the use of molecular biology tools for the exploration of the genes encoding enzymes of their synthesis pathways and their regulators. Genetic manipulation of phytoalexins has been investigated to increase the disease resistance of plants. The first example of a disease resistance resulting from foreign phytoalexin expression in a novel plant has concerned a phytoalexin from grapevine which was transferred to tobacco. Transformations were then operated to investigate the potential of other phytoalexin biosynthetic genes to confer resistance to pathogens. Unexpectedly, engineering phytoalexins for disease resistance in plants seem to have been limited to exploiting only a few phytoalexin biosynthetic genes, especially those encoding stilbenes and some isoflavonoids. Research has rather focused on indirect approaches which allow modulation of the accumulation of phytoalexin employing transcriptional regulators or components of upstream regulatory pathways. Genetic approaches using gain- or less-of functions in phytoalexin engineering together with modulation of phytoalexin accumulation through molecular engineering of plant hormones and defense-related marker and elicitor genes have been reviewed.
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