ArticleBritish journal of cancer2013
The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers.
Article in British journal of cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- An updated dose-response meta-analysis of coffee consumption and liver cancer risk.Scientific reports · 2016Pooled it
- Association of coffee drinking with all-cause mortality: a systematic review and meta-analysis.Public health nutrition · 2015Pooled it
- Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study.American journal of epidemiology · 2015Trial
- Lifestyle factors in hepatocellular carcinoma: From pathogenesis to prognosis.World journal of clinical oncology · 2025Review
- Beyond the Liver: A Comprehensive Review of Strategies to Prevent Hepatocellular Carcinoma.Journal of clinical medicine · 2024Review
- Targeted and Non-Targeted HPLC Analysis of Coffee-Based Products as Effective Tools for Evaluating the Coffee Authenticity.Molecules (Basel, Switzerland) · 2022Review
- A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer.Hepatology communications · 2022Article
- Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality.Journal of the National Cancer Institute · 2021Article
- All coffee types decrease the risk of adverse clinical outcomes in chronic liver disease: a UK Biobank study.BMC public health · 2021Article
- Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality.Journal of the National Cancer Institute · 2020Article
- Coffee Drinking and Reduced Risk of Liver Cancer: Update on Epidemiological Findings and Potential Mechanisms.Current nutrition reports · 2019Review
- Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study.Viruses · 2019Article
- Coffee and tea drinking and risk of cancer of the urinary tract in male smokers.Annals of epidemiology · 2019Article
- A Metabolomic Study of the Variability of the Chemical Composition of Commonly Consumed Coffee Brews.Metabolites · 2019Article
- Article
- Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies.Nutrients · 2017Article
- Tooth loss and liver cancer incidence in a Finnish cohort.Cancer causes & control : CCC · 2017Article
- Coffee: The magical bean for liver diseases.World journal of hepatology · 2017Review
- Coffee and cancer risk: A meta-analysis of prospective observational studies.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCoffee intake is associated with reduced risk of liver cancer and chronic liver disease as reported in previous studies, including prospective ones conducted in Asian populations where hepatitis B viruses (HBVs) and hepatitis C viruses (HCVs) are the dominant risk factors. Yet, prospective studies in Western populations with lower HBV and HCV prevalence are sparse. Also, although preparation methods affect coffee constituents, it is unknown whether different methods affect disease associations.
methodsWe evaluated the association of coffee intake with incident liver cancer and chronic liver disease mortality in 27,037 Finnish male smokers, aged 50-69, in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, who recorded their coffee consumption and were followed up to 24 years for incident liver cancer or chronic liver disease mortality. Multivariate relative risks (RRs) and 95% confidence intervals (CIs) were estimated by Cox proportional hazard models.
resultsCoffee intake was inversely associated with incident liver cancer (RR per cup per day=0.82, 95% CI: 0.73-0.93; P-trend across categories=0.0007) and mortality from chronic liver disease (RR=0.55, 95% CI: 0.48-0.63; P-trend<0.0001). Inverse associations persisted in those without diabetes, HBV- and HCV-negative cases, and in analyses stratified by age, body mass index, alcohol and smoking dose. We observed similar associations for those drinking boiled or filtered coffee.
conclusionThese findings suggest that drinking coffee may have benefits for the liver, irrespective of whether coffee was boiled or filtered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.