ArticleEpigenetics2013
Radiation-induced epigenetic DNA methylation modification of radiation-response pathways.
Article in Epigenetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 143 citations in OpenAlex.
- Reprogramming the tumor immune microenvironment in cervical cancer: synergy between radiotherapy and immunotherapy.Molecular cancer · 2026Review
- Space-Earth connection: How space weather fluctuations impact epigenetic aging in an elderly men cohort from Massachusetts, USA.medRxiv : the preprint server for health sciences · 2025Article
- Review
- In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance.Hereditas · 2025Article
- Ionizing Radiation Increases Death Receptor 5 (DR5)-Mediated Cell Death, but Not Death Receptor 4 (DR4)-Mediated Cell Death in 3D Tumor Spheroids.International journal of molecular sciences · 2025Article
- High-Fat Diet and Altered Radiation Response.Biology · 2025Review
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming.Radiation and environmental biophysics · 2025Article
- Radiation-induced intestinal injury: from molecular mechanisms to clinical translation.Oncology reviews · 2025Review
- A Prospective cohort study investigates the health consequences and biomarkers in Iraqi radiation workers.Asia Oceania journal of nuclear medicine & biology · 2025Article
- DNA methylation and prediction of biological age.Frontiers in molecular biosciences · 2025Review
- Effects of gravity, microgravity or microgravity simulation on early mouse embryogenesis: A review of the first two space embryo studies.Mechanobiology in medicine · 2024Article
- Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer.Cell death & disease · 2024Article
- Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells.Epigenetics · 2023Article
- Changes in the Level of DNA Methylation inInternational journal of molecular sciences · 2023Article
- Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts.Clinical epigenetics · 2023Article
- DNA methylome profiling in occupational radon exposure miners using an Illumina Infinium Methylation EPIC BeadChip.Toxicology research · 2023Article
- Article
- Targeting miR-5088-5p attenuates radioresistance by suppressing Slug.Non-coding RNA research · 2023Article
- Epigenetic age acceleration among survivors of pediatric medulloblastoma and primitive neuroectodermal tumor.Pediatric hematology and oncology · 2023Article
- Gene expression variability in long-term survivors of childhood cancer and cancer-free controls in response to ionizing irradiation.Molecular medicine (Cambridge, Mass.) · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
DNA methylation can regulate gene expression and has been shown to modulate cancer cell biology and chemotherapy resistance. Therapeutic radiation results in a biological response to counter the subsequent DNA damage and genomic stress in order to avoid cell death. In this study, we analyzed DNA methylation changes at>450,000 loci to determine a potential epigenetic response to ionizing radiation in MDA-MB-231 cells. Cells were irradiated at 2 and 6 Gy and analyzed at 7 time points from 1-72 h. Significantly differentially methylated genes were enriched in gene ontology categories relating to cell cycle, DNA repair, and apoptosis pathways. The degree of differential methylation of these pathways varied with radiation dose and time post-irradiation in a manner consistent with classical biological responses to radiation. A cell cycle arrest was observed 24 h post-irradiation and DNA damage, as measured by γH2AX, resolved at 24 h. In addition, cells showed low levels of apoptosis 2-48 h post-6 Gy and cellular senescence became significant at 72 h post-irradiation. These DNA methylation changes suggest an epigenetic role in the cellular response to radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.