ArticleDevelopmental biology2013
Postembryonic lineages of the Drosophila brain: I. Development of the lineage-associated fiber tracts.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
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- Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex.bioRxiv : the preprint server for biology · 2025Article
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- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- The role of cell lineage in the development of neuronal circuitry and function.Developmental biology · 2021Review
- Article
- Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation ofFrontiers in endocrinology · 2021Article
- Sequence heterochrony led to a gain of functionality in an immature stage of the central complex: A fly-beetle insight.PLoS biology · 2020Article
- Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain.Current biology : CB · 2020Article
- Beyond Host Defense: Deregulation ofFrontiers in immunology · 2020Review
- Pioneer interneurons instruct bilaterality in the Drosophila olfactory sensory map.Science advances · 2019Article
- Lineage-specific determination of ring neuron circuitry in the central complex ofBiology open · 2019Article
- Rewiring theFrontiers in molecular neuroscience · 2019Review
- Article
- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. II. Sensory compartments.The Journal of comparative neurology · 2018Article
- Neuronal Constituents and Putative Interactions Within theFrontiers in neural circuits · 2018Article
- Development of the anterior visual input pathway to the Drosophila central complex.The Journal of comparative neurology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Neurons of the Drosophila central brain fall into approximately 100 paired groups, termed lineages. Each lineage is derived from a single asymmetrically-dividing neuroblast. Embryonic neuroblasts produce 1,500 primary neurons (per hemisphere) that make up the larval CNS followed by a second mitotic period in the larva that generates approximately 10,000 secondary, adult-specific neurons. Clonal analyses based on previous works using lineage-specific Gal4 drivers have established that such lineages form highly invariant morphological units. All neurons of a lineage project as one or a few axon tracts (secondary axon tracts, SATs) with characteristic trajectories, thereby representing unique hallmarks. In the neuropil, SATs assemble into larger fiber bundles (fascicles) which interconnect different neuropil compartments. We have analyzed the SATs and fascicles formed by lineages during larval, pupal, and adult stages using antibodies against membrane molecules (Neurotactin/Neuroglian) and synaptic proteins (Bruchpilot/N-Cadherin). The use of these markers allows one to identify fiber bundles of the adult brain and associate them with SATs and fascicles of the larval brain. This work lays the foundation for assigning the lineage identity of GFP-labeled MARCM clones on the basis of their close association with specific SATs and neuropil fascicles, as described in the accompanying paper (Wong et al., 2013. Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones. Submitted.).
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