Evidence map›Paper›PMID 23880347›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2014

Plasma cis-vaccenic acid and risk of heart failure with antecedent coronary heart disease in male physicians.

Luc Djoussé, Chisa Matsumoto, Naomi Q Hanson, Natalie L Weir, Michael Y Tsai, J Michael Gaziano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luc DjousséDivision of Aging, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; The Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA. Electronic address: ldjousse@rics.bwh.harvard.edu.
Chisa MatsumotoDivision of Aging, Boston, MA, USA.
Naomi Q HansonThe University of Minnesota, Minneapolis, MN, USA.
Natalie L WeirThe University of Minnesota, Minneapolis, MN, USA.
Michael Y TsaiThe University of Minnesota, Minneapolis, MN, USA.
J Michael GazianoDivision of Aging, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; The Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research (GRECC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
University of Minnesota · USGeriatric Research Education and Clinical Center · US

Funding

Physicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7M
Fatty Acids and Heart Failure in the Physicians' Health StudyR01HL092946 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DJOUSSE, LUC · 2009 to 2013
$2.8M
RANDOMIZED TRIAL OF ASPIRIN AND MORTALITYR01CA040360 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 2002
$775k
REGULATION OF CALCIUM ACTIVATED POTASSIUM CHANNELSF32HL009294 · NHLBI · WASHINGTON UNIVERSITY · PI WANG, ZHAO-WEN · 1995 to 1998
–
TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'SR01HL034595 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1985 to 1991
–
NCI NIH HHS CA-097193NCI NIH HHS CA-34944NCI NIH HHS CA-40360NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA097193NHLBI NIH HHS HL092946S1NHLBI NIH HHS HL-26490NHLBI NIH HHS HL-34595NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL092946NHLBI NIH HHS R01HL092946
6 · The paper itself

Abstract

BACKGROUND &

aimsAlthough an inverse association of red blood cell cis-vaccenic acid and risk of myocardial infarction has been reported, it is unclear whether cis-vaccenic acid might lower the risk of heart failure (HF) with antecedent coronary heart disease (CHD). We sought to examine the relation of plasma cis-vaccenic acid with HF with antecedent CHD.

methodsThis nested case-control study was based on 788 incident HF cases (of whom 258 cases had antecedent CHD) and 788 controls. Each control was selected using a risk set sampling technique at the time of the occurrence of the index case and matched on year of birth, age at blood collection, and race. Fatty acids were measured using gas chromatography and incident HF was self-reported on annual questionnaires and validation in a subsample using medical records.

resultsIn a multivariable conditional logistic regression, the odds ratio (95% confidence interval) for HF with prior CHD were 1.0 (ref), 0.72 (0.33-1.57), 0.28 (0.12-0.67), and 0.23 (0.09-0.58) across consecutive quartiles of cis-vaccenic acid (p_trend 0.0004). Each standard deviation of cis-vaccenic acid was associated with a 41% lower risk of HF with antecedent CHD (95% CI: 17%-59%) in a multivariable adjusted model.

conclusionsOur data suggest that higher plasma levels of plasma cis-vaccenic acid may be associated with a lower risk of HF with antecedent CHD. Confirmation of these results in the general population including women and other ethnic groups is warranted.

Indexed as

AgedCase-Control StudiesConfidence IntervalsCoronary DiseaseFatty AcidsFollow-Up StudiesHeart FailureHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioOleic AcidsPhysiciansProspective Studiescis-vaccenic acidFatty AcidsOleic AcidsEpidemiologyFatty acidsHeart failureNutritionRisk factor

Identifiers

PMID23880347
PMCPMC3851975
OpenAlexW1982869008

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.