ArticleJournal of the International Neuropsychological Society : JINS2013
Development of memory for spatial locations and object/place associations in infant rhesus macaques with and without neonatal hippocampal lesions.
Article in Journal of the International Neuropsychological Society : JINS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Reevaluating the role of the hippocampus in memory: A meta-analysis of neurotoxic lesion studies in nonhuman primates.Hippocampus · 2023Pooled it
- Role of the Primate Perirhinal Cortex in Memory and Emotional Regulation: Ontogeny and Early Insults.Medical research archives · 2026Article
- Review
- Review
- Acoustic startle and prepulse inhibition deficits in adult monkeys with neonatal lesions of the hippocampus, amygdala and orbital frontal cortex.Behavioural brain research · 2023Article
- Article
- Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain.International journal of molecular sciences · 2021Article
- Clinical and Preclinical Evidence for Adverse Neurodevelopment after Postnatal Zika Virus Infection.Tropical medicine and infectious disease · 2021Review
- Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques.Nature communications · 2020Article
- Nonnavigational spatial memory performance is unaffected by hippocampal damage in monkeys.Hippocampus · 2019Article
- Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.Behavioral neuroscience · 2018Article
- Article
- Spatial Responses, Immediate Experience, and Memory in the Monkey Hippocampus.Current opinion in behavioral sciences · 2017Article
- Cognitive performance of juvenile monkeys after chronic fluoxetine treatment.Developmental cognitive neuroscience · 2017Article
- The medial temporal memory system in Down syndrome: Translating animal models of hippocampal compromise.Hippocampus · 2017Article
- An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions.Developmental psychobiology · 2017Article
- Increased anxiety-like behaviors, but blunted cortisol stress response after neonatal hippocampal lesions in monkeys.Psychoneuroendocrinology · 2017Article
- Development of relational memory processes in monkeys.Developmental cognitive neuroscience · 2016Article
- Decreased functional connectivity in dorsolateral prefrontal cortical networks in adult macaques with neonatal hippocampal lesions: Relations to visual working memory deficits.Neurobiology of learning and memory · 2016Article
- The extended trajectory of hippocampal development: Implications for early memory development and disorder.Developmental cognitive neuroscience · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This study traces the development of spatial memory abilities in monkeys and reports the effects of selective neonatal hippocampal lesions on performance across development. Two different versions of the visual paired-comparison (VPC) task were used. The VPC-Spatial-Location task tested memory for object-locations that could be solved using an egocentric spatial frame of reference and the VPC-Object-In-Place task taxed memory for spatial relations using an allocentric reference frame. Eleven rhesus macaques (6 neonatal sham-operated controls and 5 with neonatal neurotoxic hippocampal lesions) were tested on both tasks as infants (8 months), juveniles (18 months), and adults (5-6 years). Memory for spatial locations was present by 18 months of age, whereas memory for object-place relations was present only in adulthood. Also, neonatal hippocampal lesions delayed the emergence of memory for spatial locations and abolished memory for object-place associations, particularly in animals that had sustained extensive and bilateral hippocampal lesions. The differential developmental time course of spatial memory functions and of the effects of neonatal hippocampal lesions on these functions are discussed in relation to morphological maturation of the medial temporal lobe structures in monkeys. Implications of the findings for the neural basis of spatial memory development in humans are also considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.