Evidence map›Paper›PMID 23880052›Full record

ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2013

Feasibility and reproducibility of systolic right ventricular strain measurement by speckle-tracking echocardiography in premature infants.

Philip Thaler Levy, Mark R Holland, Timothy J Sekarski, Aaron Hamvas, Gautam K Singh

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05235399 (Exploring Right vEntricular Function Applicability in a Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05235399 completednot on this mapstarted 2022, after this paper: background citation

Exploring Right vEntricular Function Applicability in a Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia (REPORT - BPD Study): a Mixed Methods Observational Cohort Feasibility Study

TypeobservationalSponsorUniversity Hospital Plymouth NHS TrustRan2022 to 2023Enrolled40ConditionsBronchopulmonary Dysplasia, Right Ventricular Dysfunction, In the Perinatal PeriodArmsEcho scans
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2016
    Pooled it
  2. Normal ranges of right ventricular systolic and diastolic strain measures in children: a systematic review and meta-analysis.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2014
    Pooled it
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  18. Pulmonary Hypertension Associated with Bronchopulmonary Dysplasia: A Review.Pediatric allergy, immunology, and pulmonology · 2019
    Review
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Philip Thaler LevyDepartment of Pediatrics and the Department of Physics, Washington University School of Medicine, St. Louis, Missouri.
Mark R HollandDepartment of Pediatrics and the Department of Physics, Washington University School of Medicine, St. Louis, Missouri.
Timothy J SekarskiDepartment of Pediatrics and the Department of Physics, Washington University School of Medicine, St. Louis, Missouri.
Aaron HamvasDepartment of Pediatrics and the Department of Physics, Washington University School of Medicine, St. Louis, Missouri.
Gautam K SinghDepartment of Pediatrics and the Department of Physics, Washington University School of Medicine, St. Louis, Missouri. Electronic address: singh_g@kids.wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Data Coordinating Center for the Prematurity and Respiratory Outcomes ProgramU01HL101794 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHMIDT, BARBARA · 2010 to 2014
$10.3M
Training of the Pediatric Physician-ScientistT32HD043010 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2002 to 2026
$6.4M
Influence of the Enteric Microbiome on the Genesis of Bronchopulmonary DysplasiaU01HL101465 · NHLBI · WASHINGTON UNIVERSITY · PI FERKOL, THOMAS W, WARNER, BARBARA B · 2010 to 2014
$2.1M
BAYESIAN ENHANCEMENT OF ECHOCARDIOGRAPHIC STRAIN ASSESSMENTR21HL106417 · NHLBI · WASHINGTON UNIVERSITY · PI MILLER, JAMES GEGAN · 2012 to 2013
$409k
NCATS NIH HHS UL1 TR000448NHLBI NIH HHS 1U01 HL1014650NHLBI NIH HHS R21 HL106417NHLBI NIH HHS U01 HL101465NHLBI NIH HHS U01 HL101794NICHD NIH HHS 5 T32 HD043010-09NICHD NIH HHS T32 HD043010
6 · The paper itself

Abstract

backgroundRight ventricular (RV) systolic function is an important prognostic determinant of cardiopulmonary pathologies in premature infants. Measurements of dominant RV longitudinal deformation are likely to provide a sensitive measure of RV function. An approach for image acquisition and postacquisition processing is needed for reliable and reproducible measurements of myocardial deformation by two-dimensional (2D) speckle-tracking echocardiography. The aims of this study were to determine the feasibility and reproducibility of 2D speckle-tracking echocardiographic measurement of RV peak global longitudinal strain (pGLS) and peak global longitudinal strain rate in premature infants and to establish methods for acquiring and analyzing strain.

methodsThe study was designed in two phases: (1) a training phase to develop methods of image acquisition and postprocessing in a cohort of 30 premature infants (born at 28 ± 1 weeks) and (2) a study phase to prospectively test in a separate cohort of 50 premature infants (born at 27 ± 1 weeks) if the methods improved the feasibility and reproducibility of RV pGLS and peak global longitudinal strain rate measurements to a clinically significant level, assessed using Bland-Altman analysis (bias, limits of agreement, coefficient of variation, and intraclass correlation coefficient).

resultsStrain imaging was feasible from 84% of the acquisitions using the methods developed for optimal speckle brightness and frame rate for RV-focused image acquisition. There was high intraobserver (bias, 3%; 95% limits of agreement, -1.6 to +1.6; coefficient of variation, 2.7%; intraclass correlation coefficient, 0.97; P = .02) and interobserver (bias, 7%; 95% limits of agreement, -4.8 to +4.73; coefficient of variation, 3.9%; intraclass correlation coefficient, 0.93; P < .05) reproducibility, with excellent linear correlation between the two pGLS measurements (r = 0.97 [P < .01] and r = 0.93 [P < .05], respectively).

conclusionsThis study demonstrates high clinical feasibility and reproducibility of RV pGLS and RV peak global longitudinal strain rate measurements by 2D speckle-tracking echocardiography in premature infants and offers methods for image acquisition and data analysis for systolic strain imaging that can provide a reliable assessment of global RV function.

Indexed as

Infant, PrematureEchocardiographyFeasibility StudiesFemaleHeart VentriclesHumansImage Processing, Computer-AssistedInfant, NewbornMalePrognosisReproducibility of ResultsSystole2DCICoefficient of variationConfidence intervalCVDoppler tissue imagingDTIGlobal longitudinal strainICCIntraclass correlation coefficientLimits of agreementLOAPeak global longitudinal strainPeak global longitudinal strain ratepGLSpGLSrPMAPostmenstrual agePremature infantsRegion of interestRight ventricleRight ventricularROIRVSpeckle-tracking echocardiographySTESystolic functionTwo-dimensional

Identifiers

PMID23880052
PMCPMC3800696
OpenAlexW2038180319

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.