ReviewExpert review of anti-infective therapy2013
Photodynamic inactivation of biofilm: taking a lightly colored approach to stubborn infection.
Review in Expert review of anti-infective therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the Efficacy of Rose Bengal as a Photosensitizer in Antimicrobial Photodynamic Therapy AgainstInternational journal of molecular sciences · 2025Pooled it
- Trial
- Dissecting Cellulitis of the Scalp: Current Insights and Therapeutic Advances.American journal of clinical dermatology · 2026Review
- Dissecting Cellulitis of the Scalp: Linking Pathogenesis to Therapy.Biomedicines · 2026Review
- Dissecting Cellulitis of the Scalp: A Case Report.Cureus · 2026Article
- Emerging Multimodal Strategies for Bacterial Biofilm Eradication: A Comprehensive Review.Microorganisms · 2025Review
- Selective Targeting and Enhanced Photodynamic Inactivation of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap.Bioactive materials · 2025Review
- Toward Noninvasively Imaging pH at the Surface of Implanted Orthopedic Devices in Live Rabbits Using X-ray Excited Luminescence Chemical Imaging.Advanced healthcare materials · 2025Article
- pH-Responsive Nanophotosensitizer Boosting Antibacterial Photodynamic Therapy by Hydroxyl Radical Generation.Nanomaterials (Basel, Switzerland) · 2025Article
- Rational control of combined photothermal and photodynamic therapy for effective eradication of biofilms.Nanoscale · 2025Article
- Photodynamic Inactivation Mediated by Endogenous Porphyrins ofACS omega · 2025Article
- Assessment of photodynamic therapy efficacy againstJournal of biomedical optics · 2025Article
- Article
- Review
- Dentition Type as a Determinant of Microbial Load Reduction by Antimicrobial Photodynamic Therapy in Deep Dentin Caries: A Systematic Review and Meta-analysis.Journal of dentistry (Shiraz, Iran) · 2024Review
- In vitro antibacterial activity of photoactivated flavonoid glycosides against Acinetobacter baumannii.AMB Express · 2024Article
- Activity of Organoboron Compounds against Biofilm-Forming Pathogens.Antibiotics (Basel, Switzerland) · 2024Review
- Article
- Biofilm inhibition/eradication: exploring strategies and confronting challenges in combatting biofilm.Archives of microbiology · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Microbial biofilms are responsible for a variety of microbial infections in different parts of the body, such as urinary tract infections, catheter infections, middle-ear infections, gingivitis, caries, periodontitis, orthopedic implants, and so on. The microbial biofilm cells have properties and gene expression patterns distinct from planktonic cells, including phenotypic variations in enzymic activity, cell wall composition and surface structure, which increase the resistance to antibiotics and other antimicrobial treatments. There is consequently an urgent need for new approaches to attack biofilm-associated microorganisms, and antimicrobial photodynamic therapy (aPDT) may be a promising candidate. aPDT involves the combination of a nontoxic dye and low-intensity visible light which, in the presence of oxygen, produces cytotoxic reactive oxygen species. It has been demonstrated that many biofilms are susceptible to aPDT, particularly in dental disease. This review will focus on aspects of aPDT that are designed to increase efficiency against biofilms modalities to enhance penetration of photosensitizer into biofilm, and a combination of aPDT with biofilm-disrupting agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.