ReviewClinical & developmental immunology2013
The leech nervous system: a valuable model to study the microglia involvement in regenerative processes.
Review in Clinical & developmental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Written in the Stars: Astrocyte Biology From Evolution to Disease.Acta physiologica (Oxford, England) · 2026Review
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- The complete mitochondrial genome ofMitochondrial DNA. Part B, Resources · 2022Article
- The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration.International journal of molecular sciences · 2021Review
- A Comparative Biology of Microglia Across Species.Frontiers in cell and developmental biology · 2021Review
- Phylogenomic Analysis of a Putative Missing Link Sparks Reinterpretation of Leech Evolution.Genome biology and evolution · 2019Article
- ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion.Scientific reports · 2019Article
- Proteomic characterisation of leech microglia extracellular vesicles (EVs): comparison between differential ultracentrifugation and Optiprep™ density gradient isolation.Journal of extracellular vesicles · 2019Article
- Evolution of Neuroglia.Advances in experimental medicine and biology · 2019Review
- Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons.International journal of molecular sciences · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Connecting the nervous and the immune systems in evolution.Communications biology · 2018Article
- A new cellular type in invertebrates: first evidence of telocytes in leech Hirudo medicinalis.Scientific reports · 2017Article
- Functional Morphology of the Arm Spine Joint and Adjacent Structures of the Brittlestar Ophiocomina nigra (Echinodermata: Ophiuroidea).PloS one · 2016Article
- Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech.Scientific reports · 2015Article
- Calreticulin contributes to C1q-dependent recruitment of microglia in the leech Hirudo medicinalis following a CNS injury.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microglia are intrinsic components of the central nervous system (CNS). During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages. Functions of microglia appear to be complex as they exhibit both neuroprotective and neurotoxic effects during neuropathological conditions in vivo and in vitro. The medicinal leech Hirudo medicinalis is a well-known model in neurobiology due to its ability to naturally repair its CNS following injury. Considering the low infiltration of blood cells in this process, the leech CNS is studied to specify the activation mechanisms of only resident microglial cells. The microglia recruitment is known to be essential for the usual sprouting of injured axons and does not require any other glial cells. The present review will describe the questions which are addressed to understand the nerve repair. They will discuss the implication of leech factors in the microglial accumulation, the identification of nerve cells producing these molecules, and the study of different microglial subsets. Those questions aim to better understand the mechanisms of microglial cell recruitment and their crosstalk with damaged neurons. The study of this dialog is necessary to elucidate the balance of the inflammation leading to the leech CNS repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.