ArticleThe Journal of cell biology2013
Systematic characterization of the conformation and dynamics of budding yeast chromosome XII.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Tuning nuclear rheology through transient chromatin cross-links.Physical review. E · 2025Article
- Nuclear cholesterol regulates nuclear size and DNA damage responses in cancer stem cells.Neuro-oncology · 2025Article
- Coarse-grained chromatin dynamics by tracking multiple similarly labeled gene loci.Biophysical journal · 2025Article
- Article
- The vacuole shapes the nucleus and the ribosomal DNA loop during mitotic delays.Life science alliance · 2022Article
- Production of nascent ribosome precursors within the nucleolar microenvironment of Saccharomyces cerevisiae.Genetics · 2022Article
- Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells.Protein & cell · 2022Article
- High-Resolution Microscopy to Learn the Nuclear Organization of the Living Yeast Cells.Stem cells international · 2021Article
- Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage.Genome biology · 2020Article
- Quantitative Analysis of Spatial Distributions of All tRNA Genes in Budding Yeast.Biophysical journal · 2020Article
- Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus.Scientific reports · 2020Article
- Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes.Nucleic acids research · 2019Article
- tRNA Genes Affect Chromosome Structure and Function via Local Effects.Molecular and cellular biology · 2019Article
- Compositional reorganization of the nucleolus in budding yeast mitosis.Molecular biology of the cell · 2019Article
- From dynamic chromatin architecture to DNA damage repair and back.Nucleus (Austin, Tex.) · 2018Review
- Retrotransposon targeting to RNA polymerase III-transcribed genes.Mobile DNA · 2018Review
- Chromatin and nucleosome dynamics in DNA damage and repair.Genes & development · 2017Review
- Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus.Nucleic acids research · 2017Article
- Two loci single particle trajectories analysis: constructing a first passage time statistics of local chromatin exploration.Scientific reports · 2017Article
- Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast.The EMBO journal · 2017Article
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Authors and funding
14 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosomes architecture is viewed as a key component of gene regulation, but principles of chromosomal folding remain elusive. Here we used high-throughput live cell microscopy to characterize the conformation and dynamics of the longest chromosome of Saccharomyces cerevisiae (XII). Chromosome XII carries the ribosomal DNA (rDNA) that defines the nucleolus, a major hallmark of nuclear organization. We determined intranuclear positions of 15 loci distributed every ~100 kb along the chromosome, and investigated their motion over broad time scales (0.2-400 s). Loci positions and motions, except for the rDNA, were consistent with a computational model of chromosomes based on tethered polymers and with the Rouse model from polymer physics, respectively. Furthermore, rapamycin-dependent transcriptional reprogramming of the genome only marginally affected the chromosome XII internal large-scale organization. Our comprehensive investigation of chromosome XII is thus in agreement with recent studies and models in which long-range architecture is largely determined by the physical principles of tethered polymers and volume exclusion.
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