ArticleProceedings of the National Academy of Sciences of the United States of America2013
Ultradian metabolic rhythm in the diazotrophic cyanobacterium Cyanothece sp. ATCC 51142.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 44 citations in OpenAlex.
- Biochemical Characterization and Active-Site Analysis ofLife (Basel, Switzerland) · 2026Article
- Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Living photosynthetic micro/nano-platforms: Engineering unicellular algae for biomedical applications.Bioactive materials · 2025Review
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- The balance between photosynthesis and respiration explains the niche differentiation betweenComputational and structural biotechnology journal · 2023Article
- Coupling-dependent metabolic ultradian rhythms in confluent cells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Temporal Patterns and Intra- and Inter-Cellular Variability in Carbon and Nitrogen Assimilation by the Unicellular CyanobacteriumFrontiers in microbiology · 2021Article
- Time-of-day-dependent responses of cyanobacterial cellular viability against oxidative stress.Scientific reports · 2020Article
- Circadian clock-controlled gene expression in co-cultured, mat-forming cyanobacteria.Scientific reports · 2020Article
- Multi-omics reveals mechanisms of total resistance to extreme illumination of a desert alga.Nature plants · 2020Article
- Heterogeneous nitrogen fixation rates confer energetic advantage and expanded ecological niche of unicellular diazotroph populations.Communications biology · 2020Article
- A diurnal flux balance model of Synechocystis sp. PCC 6803 metabolism.PLoS computational biology · 2019Article
- Article
- Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Rhythms in energy storage control the ability of the cyanobacterial circadian clock to reset.Current biology : CB · 2014Article
- Daily rhythms in the cyanobacterium synechococcus elongatus probed by high-resolution mass spectrometry-based proteomics reveals a small defined set of cyclic proteins.Molecular & cellular proteomics : MCP · 2014Article
- Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.Annual review of biochemistry · 2014Review
- Metabolic and nontranscriptional circadian clocks: eukaryotes.Annual review of biochemistry · 2014Review
- Rhythmic and sustained oscillations in metabolism and gene expression of Cyanothece sp. ATCC 51142 under constant light.Frontiers in microbiology · 2013Article
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unicellular cyanobacterium Cyanothece sp. American Type Culture Collection (ATCC) 51142 is capable of performing oxygenic photosynthesis during the day and microoxic nitrogen fixation at night. These mutually exclusive processes are possible only by temporal separation by circadian clock or another cellular program. We report identification of a temperature-dependent ultradian metabolic rhythm that controls the alternating oxygenic and microoxic processes of Cyanothece sp. ATCC 51142 under continuous high irradiance and in high CO2 concentration. During the oxygenic photosynthesis phase, nitrate deficiency limited protein synthesis and CO2 assimilation was directed toward glycogen synthesis. The carbohydrate accumulation reduced overexcitation of the photosynthetic reactions until a respiration burst initiated a transition to microoxic N2 fixation. In contrast to the circadian clock, this ultradian period is strongly temperature-dependent: 17 h at 27 °C, which continuously decreased to 10 h at 39 °C. The cycle was expressed by an oscillatory modulation of net O2 evolution, CO2 uptake, pH, fluorescence emission, glycogen content, cell division, and culture optical density. The corresponding ultradian modulation was also observed in the transcription of nitrogenase-related nifB and nifH genes and in nitrogenase activities. We propose that the control by the newly identified metabolic cycle adds another rhythmic component to the circadian clock that reflects the true metabolic state depending on the actual temperature, irradiance, and CO2 availability.
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