ArticleProceedings of the National Academy of Sciences of the United States of America2013
Six-rowed spike4 (Vrs4) controls spikelet determinacy and row-type in barley.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
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Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Auxin-related regulation of barley floral organ fate: genetic and phenotypic insights from tweaky spike mutants.The New phytologist · 2026Article
- Spatial transcriptomics identifies distinct domains regulating yield-component traits of the wheat ear.Science advances · 2026Article
- Identification of adaptive selection footprints and adaptation strategies of hulless barley (Hordeum vulgare var. coeleste) on the Qinghai-Tibet Plateau.BMC genomics · 2026Article
- Genome-wide characterization of the LBD gene family in Sapindus mukorossi and functional analysis of the role of SmuLBD26 in male sterility.Plant cell reports · 2026Article
- Grass inflorescence morphodynamics guides yield improvement in wheat.Nature plants · 2026Article
- Regulation of spikelet number during wheat spike development.bioRxiv : the preprint server for biology · 2026Article
- Imputation integrates single-cell and spatial gene expression data to resolve transcriptional networks in barley shoot meristem development.Nature plants · 2026Article
- Article
- How meristems shape plant architecture in cereals-Cereal Stem Cell Systems (CSCS) Consortium.The Plant cell · 2025Review
- CLAVATA signalling shapes barley inflorescence by controlling activity and determinacy of shoot meristem and rachilla.Nature communications · 2025Article
- Article
- Multi-population GWAS detects robust marker associations in a newly established six-rowed winter barley breeding program.Heredity · 2025Article
- Watkins wheat landraces decode nitrogen-driven biomass trade-offs: GWAS exposes root-shoot dialectics and elite landraces for resilient agriculture.Frontiers in plant science · 2025Article
- AutoXAI4Omics: an automated explainable AI tool for omics and tabular data.Briefings in bioinformatics · 2024Article
- HOMEOBOX2, the paralog of SIX-ROWED SPIKE1/HOMEOBOX1, is dispensable for barley spikelet development.Journal of experimental botany · 2024Article
- Are cereal grasses a single genetic system?Nature plants · 2024Article
- Natural variations of HvSRN1 modulate the spike rachis node number in barley.Plant communications · 2024Article
- Genome-wide screening of meta-QTL and candidate genes controlling yield and yield-related traits in barley (Hordeum vulgare L.).PloS one · 2024Article
- Identification and map-based cloning of long glume mutant geneMolecular breeding : new strategies in plant improvement · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflorescence architecture of barley (Hordeum vulgare L.) is common among the Triticeae species, which bear one to three single-flowered spikelets at each rachis internode. Triple spikelet meristem is one of the unique features of barley spikes, in which three spikelets (one central and two lateral spikelets) are produced at each rachis internode. Fertility of the lateral spikelets at triple spikelet meristem gives row-type identity to barley spikes. Six-rowed spikes show fertile lateral spikelets and produce increased grain yield per spike, compared with two-rowed spikes with sterile lateral spikelets. Thus, far, two loci governing the row-type phenotype were isolated in barley that include Six-rowed spike1 (Vrs1) and Intermedium-C. In the present study, we isolated Six-rowed spike4 (Vrs4), a barley ortholog of the maize (Zea mays L.) inflorescence architecture gene RAMOSA2 (RA2). Eighteen coding mutations in barley RA2 (HvRA2) were specifically associated with lateral spikelet fertility and loss of spikelet determinacy. Expression analyses through mRNA in situ hybridization and microarray showed that Vrs4 (HvRA2) controls the row-type pathway through Vrs1 (HvHox1), a negative regulator of lateral spikelet fertility in barley. Moreover, Vrs4 may also regulate transcripts of barley SISTER OF RAMOSA3 (HvSRA), a putative trehalose-6-phosphate phosphatase involved in trehalose-6-phosphate homeostasis implicated to control spikelet determinacy. Our expression data illustrated that, although RA2 is conserved among different grass species, its down-stream target genes appear to be modified in barley and possibly other species of tribe Triticeae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.