Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Advertisements impact the physiological efficacy of a branded drug.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Oxytocin and the social facilitation of placebo effects.Molecular psychiatry · 2022Review
- The role of patient beliefs in open-label placebo effects.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Treating patients rather than their functional neuroimages. Comment on Br J Anaesth 2018; 120: 299-307.British journal of anaesthesia · 2018Article
- Harnessing the placebo effect: Exploring the influence of physician characteristics on placebo response.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- The Signaling Theory of Symptoms : An Evolutionary Explanation of the Placebo Effect.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior · 2015Article
- The neuroscience of placebo effects: connecting context, learning and health.Nature reviews. Neuroscience · 2015Review
- Current and Emerging Technologies to Address the Placebo Response Challenge in CNS Clinical Trials: Promise, Pitfalls, and Pathways Forward.Innovations in clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted randomized clinical trials to examine the impact of direct-to-consumer advertisements on the efficacy of a branded drug. We compared the objectively measured, physiological effect of Claritin (Merck & Co.), a leading antihistamine medication, across subjects randomized to watch a movie spliced with advertisements for Claritin or advertisements for Zyrtec (McNeil), a competitor antihistamine. Among subjects who test negative for common allergies, exposure to Claritin advertisements rather than Zyrtec advertisements increases the efficacy of Claritin. We conclude that branded drugs can interact with exposure to television advertisements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.