ArticleGenome research2013
Honey bee protein atlas at organ-level resolution.
Article in Genome research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Investigating trade-offs between ovary activation and immune protein expression in bumble bee (Proceedings. Biological sciences · 2024Article
- Cellular heterogeneity of the developing worker honey bee (Apis mellifera) pupa: a single cell transcriptomics analysis.G3 (Bethesda, Md.) · 2023Article
- A conserved hymenopteran-specific family of cytochrome P450s protects bee pollinators from toxic nectar alkaloids.Science advances · 2023Article
- Indirect exposure to insect growth disruptors affects honey bee (Apis mellifera) reproductive behaviors and ovarian protein expression.PloS one · 2023Article
- Article
- Drone honey bees are disproportionately sensitive to abiotic stressors despite expressing high levels of stress response proteins.Communications biology · 2022Article
- Thrice out of Asia and the adaptive radiation of the western honey bee.Science advances · 2021Article
- Organ-specific transcriptome analysis reveals differential gene expression in different castes under natural conditions in Apis cerana.Scientific reports · 2021Article
- Structure of native glycolipoprotein filaments in honeybee royal jelly.Nature communications · 2020Article
- Eusociality influences the strength of negative selection on insect genomes.Proceedings. Biological sciences · 2020Article
- The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.International journal of molecular sciences · 2019Review
- The rise and fall of major royal jelly proteins during a honeybee (Ecology and evolution · 2019Article
- In-depth Proteome of the Hypopharyngeal Glands of Honeybee Workers Reveals Highly Activated Protein and Energy Metabolism in Priming the Secretion of Royal Jelly.Molecular & cellular proteomics : MCP · 2019Article
- Bacteriophage biodistribution and infectivity from honeybee to bee larvae using a T7 phage model.Scientific reports · 2019Article
- Transcriptional Control of Honey Bee (Insects · 2018Article
- Architecture of the native major royal jelly protein 1 oligomer.Nature communications · 2018Article
- Insects with similar social complexity show convergent patterns of adaptive molecular evolution.Scientific reports · 2018Article
- Proteomics Reveals the Molecular Underpinnings of Stronger Learning and Memory in Eastern Compared to Western Bees.Molecular & cellular proteomics : MCP · 2018Article
- Beyond Royalactin and a master inducer explanation of phenotypic plasticity in honey bees.Communications biology · 2018Review
- Antennal Protein Profile in Honeybees: Caste and Task Matter More Than Age.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome sequencing has provided us with gene lists but cannot tell us where and how their encoded products work together to support life. Complex organisms rely on differential expression of subsets of genes/proteins in organs and tissues, and, in concert, evolved to their present state as they function together to improve an organism's overall reproductive fitness. Proteomics studies of individual organs help us understand their basic functions, but this reductionist approach misses the larger context of the whole organism. This problem could be circumvented if all the organs in an organism were comprehensively studied by the same methodology and analyzed together. Using honey bees (Apis mellifera L.) as a model system, we report here an initial whole proteome of a complex organism, measuring 29 different organ/tissue types among the three honey bee castes: queen, drone, and worker. The data reveal that, e.g., workers have a heightened capacity to deal with environmental toxins and queens have a far more robust pheromone detection system than their nestmates. The data also suggest that workers altruistically sacrifice not only their own reproductive capacity but also their immune potential in favor of their queen. Finally, organ-level resolution of protein expression offers a systematic insight into how organs may have developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.