ArticleEuropean journal of immunology2013
NKp46 regulates allergic responses.
Article in European journal of immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Advancements in the Study of the Immune Molecule NKp46 in Immune System-related Diseases.Clinical reviews in allergy & immunology · 2024Review
- Monocytes as an early risk factor for acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.Frontiers in immunology · 2024Article
- Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Complex interactions of cellular players in chronic Graft-versus-Host Disease.Frontiers in immunology · 2023Review
- Contributions of innate lymphocytes to allergic responses.Current opinion in allergy and clinical immunology · 2019Review
- The Natural Cytotoxicity Receptors in Health and Disease.Frontiers in immunology · 2019Review
- Role of NKp46EMBO molecular medicine · 2018Article
- Zika Virus Escapes NK Cell Detection by Upregulating Major Histocompatibility Complex Class I Molecules.Journal of virology · 2017Article
- Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression.Scientific reports · 2017Article
- Natural Killer Cells in Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation.Frontiers in immunology · 2017Review
- Natural Killer Receptor 1 Dampens the Development of Allergic Eosinophilic Airway Inflammation.PloS one · 2016Article
- NK cell abnormality and its treatment in women with reproductive failures such as recurrent pregnancy loss, implantation failures, preeclampsia, and pelvic endometriosis.Reproductive medicine and biology · 2015Review
- Identification of putative novel O-glycosylations in the NK killer receptor Ncr1 essential for its activity.Cell discovery · 2015Article
- NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization.Frontiers in immunology · 2015Article
- The use of microRNA by human viruses: lessons from NK cells and HCMV infection.Seminars in immunopathology · 2014Review
- NK cell receptor NKp46 regulates graft-versus-host disease.Cell reports · 2014Article
- Regulation of the adaptive immune system by innate lymphoid cells.Current opinion in immunology · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Natural killer (NK) cells are cytotoxic cells that are able to rapidly kill viruses, tumor cells, parasites, bacteria, and even cells considered "self". The activity of NK cells is controlled by a fine balance of inhibitory and activating signals mediated by a complex set of different receptors. However, the function of NK cells is not restricted only to the killing of target cells, NK cells also possess other properties such as the secretion of proangiogenic factors during pregnancy. Here, we demonstrate another unique NK-cell activity, namely the regulation of T-cell mediated allergic responses, which is dependent on the NK-cell specific receptor NKp46 (Ncr1 in mice). Using mice in which the Ncr1 gene has been replaced with a green fluorescent protein, we demonstrate reduced delayed-type hypersensitivity and airway hypersensitivity. Interestingly, we show that this reduction in airway hypersensitivity is due to differences in the stimulation of T cells resulting in an altered cytokine profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.