ArticleDiabetes care2013
Sex-specific associations of gestational glucose tolerance with childhood body composition.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis.Human reproduction update · 2020Pooled it
- Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2017Pooled it
- Associations of Maternal Postpartum Weight Retention and Its Components With Child BMIChildhood obesity (Print) · 2026Article
- How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future.Diabetes, obesity & metabolism · 2026Review
- Sex-specific signatures of fetal programming for gestational diabetes mellitus in umbilical cord: A cohort study from Tanzania.BMC medicine · 2026Observational
- Maternal Gestational Diabetes Mellitus Modulates Adipose Tissue Remodeling and CTRP6 Expression in a Depot- and Sex-Specific Manner in Mouse Offspring.Biomedicines · 2026Article
- In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort.Clinical epigenetics · 2025Article
- Trajectory of Cardiovascular Health Across Childhood and Adolescence.JAMA cardiology · 2025Article
- Prenatal and Perinatal Factors of Life's Essential 8 Cardiovascular Health Trajectories.JAMA network open · 2025Article
- Gestational hyperglycaemia impacts glucose control and insulin sensitivity in mouse offspring.Scientific reports · 2025Article
- Prevalence and correlates of diagnosed and probable polycystic ovary syndrome (PCOS) in a cohort of parous women.American journal of epidemiology · 2025Article
- Associations of Abnormal Maternal Glucose Regulation in Pregnancy with Offspring Adiposity, Insulin Resistance, and Adipokine Markers During Childhood and Adolescence.The Journal of pediatrics · 2024Article
- Effect of high-fat diet on the fatty acid profiles of brain in offspring mice exposed to maternal gestational diabetes mellitus.International journal of obesity (2005) · 2024Article
- The risk prediction of intergenerational transmission of overweight and obesity between mothers and infants during pregnancy.BMC pregnancy and childbirth · 2024Article
- Effects of Gestational Diabetes Mellitus and Selenium Deficiency on the Offspring Growth and Blood Glucose Mechanisms of C57BL/6J Mice.Nutrients · 2023Article
- Exposure to Gestational Diabetes and BMI Trajectories Through Adolescence: The Exploring Perinatal Outcomes Among Children Study.The Journal of clinical endocrinology and metabolism · 2023Article
- Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity.Frontiers in nutrition · 2023Article
- Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children's glucose metabolism-a longitudinal study.BMC medicine · 2022Article
- History of infertility and pregnancy outcomes in Project Viva: a prospective study.BMC pregnancy and childbirth · 2022Article
- Menstrual cycle length and adverse pregnancy outcomes among women in Project Viva.Paediatric and perinatal epidemiology · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the associations of maternal gestational glucose tolerance with offspring body composition in late childhood. RESEARCH DESIGN AND
methodsAmong 958 women in the prebirth cohort Project Viva, glucose tolerance was assessed in the second trimester by nonfasting 50-g 1-h glucose challenge test (GCT), followed if abnormal by fasting 100-g 3-h oral glucose tolerance test (OGTT). We categorized women as normoglycemic (83.3%) if GCT was ≤140 mg/dL, isolated hyperglycemia (9.1%) if GCT was abnormal but OGTT normal, intermediate glucose intolerance (IGI) (3.3%) if there was one abnormal value on OGTT, or gestational diabetes mellitus (GDM) (4.5%) if there were two or more abnormal OGTT values. Using multivariable linear regression, we examined adjusted associations of glucose tolerance with offspring overall (N=958) and central (N=760) adiposity and body composition using dual X-ray absorptiometry (DXA) measured at the school-age visit (95±10 months).
resultsCompared with that in the male offspring of normoglycemic mothers, DXA fat mass was higher in male offspring of GDM mothers (1.89 kg [95% CI 0.33-3.45]) but not in male offspring of mothers with IGI (0.06 kg [-1.45 to 1.57]). DXA trunk-to-peripheral fat mass, a measure of central adiposity, was also somewhat higher in male offspring of GDM mothers (0.04 [-0.01 to 0.09]). In girls, DXA fat mass was higher in offspring of mothers with IGI (2.23 kg [0.12-4.34]) but not GDM (-1.25 kg [-3.13 to 0.63]). We showed no association of gestational glucose tolerance with DXA lean mass.
conclusionsIn this study, only male offspring of GDM mothers manifested increased adiposity, whereas only female offspring of mothers with IGI did so. Sex differences in glycemic sensitivity may explain these findings.
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