ArticleJournal of biomedical optics2013
In vivo photoacoustic lifetime imaging of tumor hypoxia in small animals.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Endogenic transferrin-targeted cell membrane-coated biomimetic lipo-complexes for efficient targeting and enhanced antitumor efficacy in orthotopic glioblastoma.Acta pharmaceutica Sinica. B · 2026Article
- Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenationJournal of photochemistry and photobiology · 2024Article
- Photoacoustic Lifetime Imaging of Hypoxia.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Functional Imaging of Hypoxia: PET and MRI.Cancers · 2023Review
- Personalized Oncology by In Vivo Chemical Imaging: Photoacoustic Mapping of Tumor Oxygen Predicts Radiotherapy Efficacy.ACS nano · 2023Article
- Review
- Biomedical Application of Photoacoustics: A Plethora of Opportunities.Micromachines · 2022Review
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
- Review
- Review
- Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.Scientific reports · 2021Article
- Article
- Article
- Optimizing photoacoustic image reconstruction using cross-platform parallel computation.Visual computing for industry, biomedicine, and art · 2018Article
- Small Molecule Optoacoustic Contrast Agents: An Unexplored Avenue for Enhancing In Vivo Imaging.Molecules (Basel, Switzerland) · 2018Review
- Transient Triplet Differential (TTD) Method for Background Free Photoacoustic Imaging.Scientific reports · 2018Article
- Photoacoustic tomography of blood oxygenation: A mini review.Photoacoustics · 2018Review
- Oxygen-generating Hybrid Polymeric Nanoparticles with Encapsulated Doxorubicin and Chlorin e6 for Trimodal Imaging-Guided Combined Chemo-Photodynamic Therapy.Theranostics · 2018Article
- Article
- In Vivo Electrical Conductivity Contrast Imaging in a Mouse Model of Cancer Using High-Frequency Magnetoacoustic Tomography With Magnetic Induction (hfMAT-MI).IEEE transactions on medical imaging · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Tumor hypoxia is an important factor in assessment of both cancer progression and cancer treatment efficacy. This has driven a substantial effort toward development of imaging modalities that can directly measure oxygen distribution and therefore hypoxia in tissue. Although several approaches to measure hypoxia exist, direct measurement of tissue oxygen through an imaging approach is still an unmet need. To address this, we present a new approach based on in vivo application of photoacoustic lifetime imaging (PALI) to map the distribution of oxygen partial pressure (pO2) in tissue. This method utilizes methylene blue, a dye widely used in clinical applications, as an oxygen-sensitive imaging agent. PALI measurement of oxygen relies upon pO2-dependent excitation lifetime of the dye. A multimodal imaging system was designed and built to achieve ultrasound (US), photoacoustic, and PALI imaging within the same system. Nude mice bearing LNCaP xenograft hindlimb tumors were used as the target tissue. Hypoxic regions were identified within the tumor in a combined US/PALI image. Finally, the statistical distributions of pO2 in tumor, normal, and control tissues were compared with measurements by a needle-mounted oxygen probe. A statistically significant drop in mean pO2 was consistently detected by both methods in tumors.
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Registered trials
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